[The effect of non-steroidal anti-inflammatory drugs on upper gastrointestinal disorders in orthopaedic patients]

[The effect of non-steroidal anti-inflammatory drugs on upper gastrointestinal disorders in orthopaedic patients] Research Abstract Details 

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Yuji Uchio,Ryuji Mori,Junji Iwasa,Hiroyuki Kakimaru,Soichiro Yamamoto,Hidetoshi Yamaguchi,Wataru Miyamoto,Yuji Uchio,Ryuji Mori,Junji Iwasa,Hiroyuki Kakimaru,Soichiro Yamamoto,Hidetoshi Yamaguchi,Wataru Miyamoto,Yuji Uchio,Ryuji Mori,Junji Iwasa,Hiroyuki Kakimaru,Soichiro Yamamoto,Hidetoshi Yamaguchi,Wataru Miyamoto,

We investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on upper gastrointestinal(GI) disorders in orthopaedic patients. Among a total of 1,923 patients (946 men and 977 women, mean age: 53 years) who received NSAIDs, 486 patients (25%) experienced some adverse reactions including mild GI symptoms, 364 patients (19%) had gastric mucosal lesion, and 37 patients (2%) had gastric ulcer. The number of patients with upper GI disorders was significantly higher in patients aged 50 years or older, than those under 50 years. Irrespective of the kinds of NSAIDs applied, our results suggest an increased risk of adverse effect causing upper GI disorders in orthopaedic patients who are administered NSAIDs for a long-term.

[The effect of non-steroidal anti-inflammatory drugs on upper gastrointestinal disorders in orthopaedic patients] Publishing Authors By Initials

Y Uchio,R Mori,J Iwasa,H Kakimaru,S Yamamoto,H Yamaguchi,W Miyamoto,Y Uchio,R Mori,J Iwasa,H Kakimaru,S Yamamoto,H Yamaguchi,W Miyamoto,Y Uchio,R Mori,J Iwasa,H Kakimaru,S Yamamoto,H Yamaguchi,W Miyamoto,

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[The effect of non-steroidal anti-inflammatory drugs on upper gastrointestinal disorders in orthopaedic patients] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nippon rinsho. Japanese journal of clinical medici

VOLUME: 65

Page Numbers: 1906-11

Journal Abbreviation: Nippon Rinsho

ISSN: 0047-1852

DAY: 10

MONTH: Oct

YEAR: 2007

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LANGUAGE: jpn

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AFFILIATION: Department of Orthopaedic Surgery, Shimane University School of Medicine.

Country: Japan

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MEDLINETA: Nippon Rinsho

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