The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.

The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Research Abstract Details 

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The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Abstract Text:

The effect of nifedipine (BAY 1040), a calcium-antagonistic inhibitor of the electromechanical coupling process was tested on atrioventricular conduction and refractoriness of the dog heart in situ by means of His-bundle electrography and programmed electrical stimulation. The animals were anaesthetized with sodium pentobarbital. As the basic effects of the compound can be altered by release of catecholamines from sympathetic nerves of heart and vessels, the dogs were pretreated with acebutolol, a beta-adrenergic receptor blocking agent, which decreased heart rate and prolonged atrioventricular conduction and refractoriness. Nifedipine 1,6 and particularly 30 microgram/kg body weight increased the heart rate and decreased atrioventricular conduction time during atrial pacing, whereas atrioventricular conduction time during sinus rhythm and atrioventricular refractoriness were only affected by nifedipine 30 microgram/kg. In this respect, nifedipine differs distinctly from another calcium antagonistic compound, verapamil.

The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Publishing Authors By Initials

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The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pharmacologica et toxicologica

VOLUME: 42

Page Numbers: 287-91

Journal Abbreviation:

ISSN: 0001-6683

DAY: 25

MONTH: Apr

YEAR: 1978

The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370572

The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Keywords Mesh Terms:

KEYWORDS: Verapamil

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. Information

Substance Name: Verapamil

Registry Number: 52-53-9

Grant and Affiliation Information for The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.

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Country: DENMARK

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MEDLINETA: Acta Pharmacol Toxicol (Copenh

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