The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population.

The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Research Abstract Details 

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The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Abstract Text:

Jhodie R Duncan,Leslie L Randall,Richard A Belliveau,Felicia L Trachtenberg,Bradley Randall,Donald Habbe,Federick Mandell,Thomas K Welty,Solomon Iyasu,Hannah C Kinney,Jhodie R Duncan,Leslie L Randall,Richard A Belliveau,Felicia L Trachtenberg,Bradley Randall,Donald Habbe,Federick Mandell,Thomas K Welty,Solomon Iyasu,Hannah C Kinney,

The high rate of the sudden infant death syndrome (SIDS) in American Indians in the Northern Plains (3.5/1000) may reflect the high incidence of cigarette smoking and alcohol consumption during pregnancy. Nicotine, a neurotoxic component of cigarettes, and alcohol adversely affect nicotinic receptor binding and subsequent cholinergic development in animals. We measured (3)H-nicotine receptor binding in 16 brainstem nuclei in American Indian SIDS (n = 27) and controls (n = 6). In five nuclei related to cardiorespiratory control, (3)H-nicotinic binding decreased with increasing number of drinks (P < 0.03). There were no differences in binding in SIDS compared with controls, except upon stratification of prenatal exposures. In three mesopontine nuclei critical for arousal there were reductions (P < 0.04) in binding in controls exposed to cigarette smoke compared with controls without exposure; there was no difference between SIDS cases with or without exposure. This study suggests that maternal smoking and alcohol affects (3)H-nicotinic binding in the infant brainstem irrespective of the cause of death. It also suggests that SIDS cases are unable to respond to maternal smoking with the "normal" reduction seen in controls. Future studies are needed to establish the role of adverse prenatal exposures in altered brainstem neurochemistry in SIDS.

The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Publishing Authors By Initials

JR Duncan,LL Randall,RA Belliveau,FL Trachtenberg,B Randall,D Habbe,F Mandell,TK Welty,S Iyasu,HC Kinney,JR Duncan,LL Randall,RA Belliveau,FL Trachtenberg,B Randall,D Habbe,F Mandell,TK Welty,S Iyasu,HC Kinney,

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The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain pathology (Zurich, Switzerland)

VOLUME: 18

Page Numbers: 21-31

Journal Abbreviation: Brain Pathol.

ISSN: 1015-6305

DAY: 9

MONTH: 10

YEAR: 2007

The effect of maternal smoking and drinking during pregnancy upon (3)h-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Information

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LANGUAGE: eng

NlmUniqueID: 9216781

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AFFILIATION: Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USA.

Country: Switzerland

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MEDLINETA: Brain Pathol

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