The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells.

The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Research Abstract Details 

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The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Abstract Text:

Hye-Ock Jang,Ji-Suk Kim,Woo-Cheol Kwon,Jeong-Kuk Kim,Myung-Suk Ko,Dong-Hoo Kim,Won-Il Kim,Young-Chan Jeon,In-Kyo Chung,Sang-Hun Shin,Jin Chung,Moon-Kyung Bae,Il Yun,

To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). Pb2+ inhibited the immediate CRACI dose-dependent manner. Influx of Pb2+ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of Pb2+ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of Ca2+ upon Ca2+ readdition, is partially inhibited by Pb2+ and (2) the influx of Pb2+ was enhanced after CRACI had been induced.

The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Publishing Authors By Initials

HO Jang,JS Kim,WC Kwon,JK Kim,MS Ko,DH Kim,WI Kim,YC Jeon,IK Chung,SH Shin,J Chung,MK Bae,I Yun,

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The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of pharmacal research

VOLUME: 31

Page Numbers: 188-94

Journal Abbreviation: Arch. Pharm. Res.

ISSN: 0253-6269

DAY: 27

MONTH: Feb

YEAR: 2008

The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Information

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LANGUAGE: eng

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AFFILIATION: Department of Dental Pharmacology, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Busan 602-739, Korea.

Country: Korea (South)

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MEDLINETA: Arch Pharm Res

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