The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia.

The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Research Abstract Details 

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The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Abstract Text:

K H Teoh,D A Mickle,R D Weisel,M M Madonik,J Ivanov,R D Harding,A D Romaschin,G J Wilson,J C Mullen,

Impaired myocardial fatty acid and glucose metabolism following ischemia and cardioplegia may limit the recovery of myocardial oxidative metabolism and ventricular function. Lactate, a simple three carbon compound, can be readily metabolized to pyruvate and is possibly the preferred substrate for aerobic metabolism. Therefore, increasing arterial lactate concentrations may improve myocardial metabolic recovery after ischemia and cardioplegia. Myocardial lactate metabolism and ventricular function were assessed in a canine model of 45 mins of global normothermic ischemia followed by 60 mins of cold potassium cardioplegic arrest. Thirteen dogs received a perioperative infusion of sodium lactate to elevate arterial concentrations (from 6 to 12 mmol/L) and 12 dogs received an equivalent amount of saline. The high arterial lactate concentrations were associated with an increased myocardial lactate consumption and oxidation (as assessed by 14C-labelled lactate) during reperfusion. Myocardial ATP concentrations fell during reperfusion despite improved myocardial oxidation. The recovery of ventricular function (as assessed by a compliant intraventricular balloon) was incomplete and only marginally better with the high arterial lactate concentrations. An infusion of lactate improved myocardial oxidative metabolism following ischemia and cardioplegia. However, the recovery of ventricular function was incomplete perhaps because of inadequate preservation of myocardial ATP.

The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Publishing Authors By Initials

KH Teoh,DA Mickle,RD Weisel,MM Madonik,J Ivanov,RD Harding,AD Romaschin,GJ Wilson,JC Mullen,

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The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Canadian journal of cardiology

VOLUME: 6

Page Numbers: 38-46

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: 04

YEAR: 2008

The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Information

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LANGUAGE: eng

NlmUniqueID: 8510280

The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Keywords Mesh Terms:

KEYWORDS: Phosphocreatine

MESH TERMS: metabolism

Chemical & Substance for Abstract: The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia. Information

Substance Name: Phosphocreatine

Registry Number: 67-07-2

Grant and Affiliation Information for The effect of lactate infusion on myocardial metabolism and ventricular function following ischemia and cardioplegia.

AFFILIATION: Division of Cardiovascular Surgery, Toronto General Hospital, Ontario.

Country: CANADA

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MEDLINETA: Can J Cardiol

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