The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake.

The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Research Abstract Details 

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The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Abstract Text:

Jamal Balouch,I Mark Olfert,Peter D Wagner,Susan R Hopkins,

The open circuit acetylene uptake method is a useful non-invasive means of measuring cardiac output. However, because of accumulation of inhaled acetylene in tissues, the cardiac output uptake is underestimated, if residual acetylene is not allowed to wash out completely in between measurements. We determined the effect of applying a correction factor that estimates mixed venous acetylene concentration from endtidal values to the calculation of cardiac output. This accounts for mixed venous acetylene present during measurements made before complete washout. Six healthy subjects performed steady-state exercise at approximately 30% and 60% of V(O2 max). Cardiac output measurements were made at each exercise intensity using the open circuit acetylene uptake method (inspired [acetylene] approximately 1%), with the first and last measurements having no detectible levels of acetylene in expired gas (reference measurement). Data were also obtained with immediate pre-measurement endtidal concentrations ranging from 3% to 15% of the inspired [acetylene], in random order in between. Oxygen consumption, carbon dioxide production and heart rate did not change significantly during testing at each exercise intensity. Reference cardiac output also did not change significantly and averaged 11.1+/-0.8 L/min at 30% of V(O2 max) and 16.5+/-2.0 L/min at 60% of V(O2 max). Uncorrected cardiac output measurements progressively underestimated cardiac output by 15% at the 3% of inspired endtidal [acetylene] and by over 50% at 15% [acetylene] (p<0.0001). However, when corrected for residual endtidal [acetylene], cardiac outputs were not significantly different from the reference measurements. The results of this study suggest that by accounting for residual endtidal acetylene in mixed venous blood, cardiac output can be accurately measured even when washout of acetylene is incomplete, allowing measurements as often as every 10-15 s.

The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Publishing Authors By Initials

J Balouch,IM Olfert,PD Wagner,SR Hopkins,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Respiratory physiology & neurobiology

VOLUME: 155

Page Numbers: 177-83

Journal Abbreviation:

ISSN: 1569-9048

DAY: 22

MONTH: 05

YEAR: 2006

The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101140022

The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake. Information

Substance Name: Helium

Registry Number: 7440-59-7

Grant and Affiliation Information for The effect of incomplete acetylene washout on cardiac output measurement using open circuit acetylene uptake.

AFFILIATION: Department of Medicine, Division of Physiology, University of California, San Diego, La Jolla, California 92093-0623, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: HL17731

ACRONYM: HL

MEDLINETA: Respir Physiol Neurobiol

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