The effect of home characteristics on dust antigen concentrations and loads in homes.

The effect of home characteristics on dust antigen concentrations and loads in homes. Research Abstract Details 

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The effect of home characteristics on dust antigen concentrations and loads in homes. Abstract Text:

Seung-Hyun Cho,Tiina Reponen,David I Bernstein,Rolanda Olds,Linda Levin,Xiaolei Liu,Kimberly Wilson,Grace Lemasters,Seung-Hyun Cho,Tiina Reponen,David I Bernstein,Rolanda Olds,Linda Levin,Xiaolei Liu,Kimberly Wilson,Grace Lemasters,

On-site home visits, consisting of a home inspection, dust sampling, and questionnaires were conducted in 777 homes belonging to an ongoing birth cohort study in Cincinnati, Ohio. Various home characteristics were investigated, and antigen levels (concentrations [microg/g] and loadings [microg/m(2)]; IU for cockroach allergen) in floor dust samples collected in child's primary activity room were analyzed by ELISA. Monoclonal antibodies were used for the analysis of cat, house dust mite, and cockroach allergens, and polyclonal antibodies for Alternaria and dog antigens. The relationship between the antigen levels and home characteristics was investigated through a generalized multiple regression model. More than half of the homes experienced mold/water damage. Cats and dogs were present in 19.7% and 31.1% of homes, respectively. More than 90% of homes had either carpet or area rug covering their floors. Among 777 homes, 87-92% of homes had measurable amount of Alternaria, cat, and dog allergen/antigen in house dust, whereas only 38% and 14% of homes had measurable levels of house dust mite and cockroach, respectively. Alternaria antigen level in house dust was not associated with visual mold/water damage, which was suspected to be one of the sources for this antigen in homes. Instead, the antigen level was high in samples taken in fall and in homes having dogs implicating that Alternaria antigen appears to be transported from outdoors to indoors. A high level was also measured in homes using a dehumidifier (these homes have experienced excessive humidity) and in-home venting of clothes dryer, which might be associated with microclimate affecting mold growth and spore release. The allergen/antigen level (both concentration and loading) of cat, dog and cockroach was significantly associated with the number of cats and dogs, or the appearance of cockroaches, respectively. High level of house dust mite allergen was measured in bedrooms and in homes using dehumidifier and no central forced air heating system. Having indoor plants was shown to reduce allergen levels. Carpeted floor was found to hold larger amount of antigens than non-carpeted floor. Antigen loading demonstrated more consistent and larger numbers of associations with home characteristics compared to antigen concentration. This study encompassed a wide range of home characteristics and various antigen types. Our findings provide information on home characteristics that can be used for allergen avoidance and in planning future exposure assessment studies.

The effect of home characteristics on dust antigen concentrations and loads in homes. Publishing Authors By Initials

SH Cho,T Reponen,DI Bernstein,R Olds,L Levin,X Liu,K Wilson,G Lemasters,SH Cho,T Reponen,DI Bernstein,R Olds,L Levin,X Liu,K Wilson,G Lemasters,

For similar animals: invertebrates: arthropods: arachnida: acari: mites: pyroglyphidae research abstracts see: animals: invertebrates: arthropods: arachnida: acari: mites: pyroglyphidae research

PUBMED ID PMID:

MEDLINE DATE:

The effect of home characteristics on dust antigen concentrations and loads in homes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Science of the total environment

VOLUME: 371

Page Numbers: 31-43

Journal Abbreviation: Sci. Total Environ.

ISSN: 0048-9697

DAY: 16

MONTH: 10

YEAR: 2006

The effect of home characteristics on dust antigen concentrations and loads in homes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 330500

The effect of home characteristics on dust antigen concentrations and loads in homes. Keywords Mesh Terms:

KEYWORDS: Pyroglyphidae

MESH TERMS: immunology

Chemical & Substance for Abstract: The effect of home characteristics on dust antigen concentrations and loads in homes. Information

Substance Name: Dust

Registry Number: 0

Grant and Affiliation Information for The effect of home characteristics on dust antigen concentrations and loads in homes.

AFFILIATION: Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.

Country: Netherlands

AGENCY: United States NIEHS

GRANT: R01 ES11170

ACRONYM: ES

MEDLINETA: Sci Total Environ

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