The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks.

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Research Abstract Details 

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The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Abstract Text:

L Fejerman,X Wu,A Adeyemo,A Luke,X Zhu,C Hicks,R S Cooper,

Molecular variants of angiotensinogen (AGT) have been associated with AGT level and hypertension (HT). However, results from reported studies vary considerably between- and within-studied populations. We performed association analysis of AGT gene variants with AGT levels and HT in samples of African descent families, including 595 Nigerians and 901 African Americans. We evaluated association using haplotypes defined by a set of single-nucleotide polymorphisms selected from a previous detailed study of the gene haplotype structure. In the sample of Nigerian families, AGT haplotype H1 was associated with high plasma level. Results were not significant for blood pressure (BP) or HT. For the African-American population, we found significant association between low plasma AGT level and haplotype H7. Furthermore, we found weak associations of H1 with hypertensive status and H7 with low systolic BP. However, no significant association between H1 and high plasma level was found. We conclude that the two distantly related haplotypes, H1 and H7, are associated, but have opposite effects on the phenotypes in two populations of African origin.

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Publishing Authors By Initials

L Fejerman,X Wu,A Adeyemo,A Luke,X Zhu,C Hicks,RS Cooper,

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The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of human hypertension

VOLUME: 20

Page Numbers: 882-7

Journal Abbreviation:

ISSN: 0950-9240

DAY: 14

MONTH: 09

YEAR: 2006

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8811625

The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Keywords Mesh Terms:

KEYWORDS: Predictive Value of Tests

MESH TERMS: ethnology

Chemical & Substance for Abstract: The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks. Information

Substance Name: Angiotensinogen

Registry Number: 11002-13-4

Grant and Affiliation Information for The effect of genetic variation in angiotensinogen on serum levels and blood pressure: a comparison of Nigerians and US blacks.

AFFILIATION: Department of Biological Anthropology, University of Oxford, Oxford, UK. laura.fejerman@hotmail.com

Country: England

AGENCY: United States NHLBI

GRANT: HL53353

ACRONYM: HL

MEDLINETA: J Hum Hypertens

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