The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs.

The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs. Research Abstract Details 

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The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs. Abstract Text:

Hizuru Miyamoto,Hiroomi Onuma,Hisao Shigematsu,Seiji Suzuki,Hideaki Sakashita,Hizuru Miyamoto,Hiroomi Onuma,Hisao Shigematsu,Seiji Suzuki,Hideaki Sakashita,

PURPOSE: The purpose of this study was to test the effect of etodolac on a dog model of osteoarthritic temporomandibular joints (TMJ). MATERIAL AND METHODS: Ten adult beagle dogs underwent surgery to induce osteoarthritis in the right TMJ, and were then randomly divided into two groups each of 5 dogs. From 2 to 6 weeks after surgery, the dogs in group 1 (control group) were given an empty gelatin capsule daily, and the dogs in group 2 (study group) were given 15mg/kg of etodolac daily. All joints were examined radiologically and histologically 8 weeks postoperatively. RESULTS: In group 1, the operated right joints showed severe osteoarthritic changes in the condyle and severe morphological differences in comparison with the unoperated (left joint). Group 2 showed fewer morphological differences between the unoperated control (left) and the operated (right) TMJ. Osteoarthritic changes in the TMJ were significantly less severe in group 2 (etodolac) than in group 1. CONCLUSION: Oral administration of etodolac at a dose of 15mg/kg minimized the continuation of experimentally induced osteoarthritic changes in the canine TMJ, when compared with the placebo. Thus, etodolac may play a role in preventing progression of human TMJ osteoarthritis.

The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs. Publishing Authors By Initials

H Miyamoto,H Onuma,H Shigematsu,S Suzuki,H Sakashita,H Miyamoto,H Onuma,H Shigematsu,S Suzuki,H Sakashita,

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The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cranio-maxillo-facial surgery : officia

VOLUME: 35

Page Numbers: 358-63

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ISSN: 1010-5182

DAY: 25

MONTH: 10

YEAR: 2007

The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs. Information

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LANGUAGE: eng

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AFFILIATION: Second Division of Oral and Maxillofacial Surgery (Chairman: Professor Hideaki Sakashita), Department of Diagnosis & Therapeutic Science, Meikai University School of Dentistry, Sakado, Saitama, Japan.

Country: Scotland

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MEDLINETA: J Craniomaxillofac Surg

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