The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause.

The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause. Research Abstract Details 

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The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause. Abstract Text:

Asli Somunkiran,Abdurrahman Coskun,Fuat Demirci,Oguz Yucel,

The aim of the present prospective controlled study was to examine the influence of 17beta-estradiol and tibolone on tumor necrosis factor-alpha (TNF-alpha) levels in healthy women with surgical menopause. Forty-five surgically menopausal women were included in the study. Thirty women were randomized to receive tibolone 2.5 mg or 17beta-estradiol 2 mg daily for 16 weeks. Fifteen surgically menopausal women who refused hormone therapy served as controls. Serum was collected from the subjects at baseline and at the end of the study for TNF-alpha assay. Neither tibolone nor 17beta-estradiol showed a significant influence on TNF-alpha level at the end of 16 weeks in comparison with baseline. Although tibolone induced a trend toward decreased level of TNF-alpha (3.30 +/- 0.42 vs. 2.56 +/- 1.94 mug/dl), this was non-significant. The slight increase observed in TNF-alpha level in the control group was also insignificant (3.60 +/- 1.20 vs. 4.10 +/- 0.70 mug/dl). Overall, these results demonstrate no significant effects of either tibolone or 17beta-estradiol on circulating TNF-alpha level in surgically menopausal women. However, the significant difference achieved between the tibolone and control group after treatment is promising and needs to be investigated in trials with longer treatment periods.

The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause. Publishing Authors By Initials

A Somunkiran,A Coskun,F Demirci,O Yucel,

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The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gynecological endocrinology : the official journal

VOLUME: 24

Page Numbers: 79-83

Journal Abbreviation: Gynecol. Endocrinol.

ISSN: 0951-3590

DAY: 22

MONTH: Feb

YEAR: 2008

The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause. Information

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LANGUAGE: eng

NlmUniqueID: 8807913

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Grant and Affiliation Information for The effect of different preparations of hormone therapy on tumor necrosis factor-alpha levels in women with surgical menopause.

AFFILIATION: Department of Obstetrics and Gynecology, School of Medicine, Duzce University, Konuralp, Turkey.

Country: England

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MEDLINETA: Gynecol Endocrinol

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