The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory.

The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory. Research Abstract Details 

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The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory. Abstract Text:

John C Ashton,Paul F Smith,Cynthia L Darlington,John C Ashton,Paul F Smith,Cynthia L Darlington,

The cannabinoid Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is currently being employed or tested for a number of therapeutic uses. Cannabinoid CB1 receptors are critically involved in adverse memory extinction. It is not known whether an unintended effect of Delta(9)-THC is increased extinction rates of adverse memories. We therefore tested the effect of Delta(9)-THC on adverse memory extinction using an auditory-stimulus/foot shock paradigm. We found that repeated administration of a high dose of Delta(9)-THC over 6 days retarded extinction compared with controls. This is in contrast to other reports and might be a result of endocannabinoid signalling dysfunction due to cannabinoid receptor densensitization.

The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory. Publishing Authors By Initials

JC Ashton,PF Smith,CL Darlington,JC Ashton,PF Smith,CL Darlington,

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The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmacology

VOLUME: 81

Page Numbers: 18-20

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ISSN: 1423-0313

DAY: 28

MONTH: 08

YEAR: 2007

The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand. john.ashton@stonebow.otago.ac.nz

Country: Switzerland

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MEDLINETA: Pharmacology

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