The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis.

The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Research Abstract Details 

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The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Abstract Text:

W T Yuh,E T Tali,H D Nguyen,T M Simonson,N A Mayr,D J Fisher,

PURPOSE: To evaluate the effect of MR contrast dose versus delayed imaging time on the detection of metastatic brain lesions based on lesion size. METHODS: Contrast MR examinations with gadoteridol were obtained in 45 patients with brain metastases. The patients were divided into two groups: 16 received cumulative standard dose (0.1 mmol/kg) and 29 received cumulative triple dose (0.3 mmol/kg). Both groups were evaluated at two dose levels (lower dose and higher dose) with two separate injections. Each patient received an initial bolus injection of either 0.05 (cumulative standard dose) or 0.1 (cumulative triple dose) mmol/kg of gadoteridol to reach the lower-dose level and underwent imaging immediately and 10 and 20 minutes later. Thirty minutes after injection, an additional bolus injection of 0.05 (cumulative standard dose) or 0.2 (cumulative triple dose) mmol/kg was administered to reach the cumulative higher-dose level (cumulative standard dose, 0.1 mmol/kg; cumulative triple dose, 0.3 mmol). Images were acquired immediately. RESULTS: There was no difference in the detection rate for lesions larger than 10 mm among T2-weighted, lower-dose immediate and delayed, or immediate higher-dose images in both study groups. Lesions smaller than 10 mm had improved detection with delayed imaging in both study groups; however, the immediate higher-dose studies still had the highest detection rate. CONCLUSION: In the evaluation of small central nervous system metastases, either delayed imaging after the injection of standard contrast dose or higher contrast dose may improve their detection, and therefore affect clinical management. Higher contrast dose (cumulative triple dose) studies appear to be more effective than delayed imaging with standard dose.

The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Publishing Authors By Initials

WT Yuh,ET Tali,HD Nguyen,TM Simonson,NA Mayr,DJ Fisher,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Journal Published:

PUBLICATION TYPE: Multicenter Study

Journal: AJNR. American journal of neuroradiology

VOLUME: 16

Page Numbers: 373-80

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: Feb

YEAR: 1995

The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis. Information

Substance Name: gadoteridol

Registry Number: 112188-16-6

Grant and Affiliation Information for The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis.

AFFILIATION: Department of Radiology, University of Iowa College of Medicine, Iowa City, USA.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

REFSOURCE: AJNR Am J Neuroradiol 1995 Jun-Jul;16(6)

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