The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Research Abstract Details 

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The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Abstract Text:

There is a growing body of evidence to suggest that cytokines may be involved in the aetiology of alcoholic hepatitis. To study the effects of chronic ethanol feeding on cytokine production we have maintained rats on the control and ethanol-containing forms of the Lieber-DeCarli liquid diet for six weeks. The animals were then given an i.v. injection of endotoxin to induce hepatitis. It was found that the ethanol-fed animals had biochemical and histological evidence of mild to severe liver damage whereas control-fed animals had minimal liver damage. When plasma levels of cytokines were measured, it was found that the ethanol-fed rats produced much higher levels of tumour necrosis factor and interleukin 6 bioactivity than the control-fed rats. However, elevated levels of interleukin 1 protein were not seen in the ethanol-fed animals.

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Publishing Authors By Initials

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 2

Page Numbers: 447-51

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1994

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Information

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LANGUAGE: eng

NlmUniqueID: 8804836

The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.

AFFILIATION: Department of Biochemistry, University of Queensland, Australia.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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