The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients.

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Abstract Text:

S Sandstedt,G Cederblad,M Lindholm,J Larsson,

To analyse the effects of L-carnitine supplemented TPN on lipid, energy and nitrogen metabolism, 16 severely injured patients were studied during the first 8 days after trauma. An L-carnitine solution (3g = 18.6mmol) was added to the fat emulsion and infused over 16h in a blind randomised fashion to half of the patients. Plasma triglyceride, free fatty acid and 3-OH-butyrate concentrations increased during the fat infusion, and fell to pre-infusion concentrations within 24h. There were no differences in plasma levels before, during or after infusion between the groups. ATP and phosphocreatine in muscle tissue were not influenced by carnitine supplementation. Glycogen, however, remained unchanged in the carnitine group and fell in the non-carnitine group. A cumulative N-balance measured from day 2 to day 8 was equally negative in both groups. Plasma carnitine levels were significantly higher in the supplemented group from day 3. The mean daily urinary carnitine excretion was increased 15-fold in the supplemented group. Muscle carnitine, however, remained unchanged in both groups and did not differ between them. The present results do not demonstrate any beneficial effects of parenterally administered L-carnitine on lipid, energy or nitrogen metabolism except for maintaining normal muscle glycogen levels in critically ill patients receiving TPN during the early phase after trauma.

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Publishing Authors By Initials

S Sandstedt,G Cederblad,M Lindholm,J Larsson,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nutrition (Edinburgh, Scotland)

VOLUME: 10

Page Numbers: 97-104

Journal Abbreviation:

ISSN: 0261-5614

DAY: 14

MONTH: Apr

YEAR: 1991

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309603

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients.

AFFILIATION: Department of Anaesthesiology, University Hospital Linköping, Sweden.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients Related Publications

• A Comparison of Speed and Accuracy of Contouring using Mouse versus Graphics Tablet.
• A porcine model of acute quadriplegic myopathy: a feasibility study.
• Adenosine is not a direct GHSR agonist--artificial cross-talk between GHSR and adenosine receptor pathways.
• Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
• Changes in muscle and plasma amino acid metabolism in severe malnutrition - The influence of total parenteral nutrition.
• Comparison of broad-range bacterial PCR and culture of cerebrospinal fluid for diagnosis of community-acquired bacterial meningitis.
• Effect of starvation on work capacity and voluntary skeletal muscle function in man.
• Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres.
• Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres.
• Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity.
• Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice.
• Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression.
• Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube.
• More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report.
• Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).
• Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.
• Perspectives on the adoption of emergency contraceptive pills as a new contraceptive method.
• Predictive Factors of Acute Transient Cord Injury (L'hermitte Syndrome) in Head and Neck Patients Treated with IMRT.
• Preventing pregnancy: a girls' issue. Seventeen-year-old Swedish boys' perceptions on abortion, reproduction and use of contraception.
• Primary vaccination and revaccination of young adults with BCG: a study using immunological markers.
• Rural parents' perceptions of risks associated with their children's exposure to radon.
• Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size.
• Sensitive and robust gene expression changes in fish exposed to estrogen--a microarray approach.
• Speed and Accuracy of Contouring using Digitising Input Devices.
• The effect of a fat emulsion on some common clinical chemical analyses.
• The effect of carnitine supplemented total parenteral nutrition on lipid, energy and nitrogen metabolism in severely ill patients.
• The effect of starvation on skeletal muscle function in man.
• The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.
• The impact of leucine infusion on skeletal muscle amino acid and energy metabolism in severely traumatized patients.
• Treatment improves quality of life in patients with poor perception of asthma.