The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture.

The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Research Abstract Details 

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The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Abstract Text:

David T Redden,David B Allison,

Spurious associations due to confounding factors are an often cited and intensely debated concern for genetic association studies. Great attention has been focused upon the specific threat of confounding due to population stratification. This emphasis has spurred the development of many statistical genetic methods to detect and correct for the potentially confounding effects of admixture. Unfortunately, this emphasis on admixture has led some authors to suggest that if ethnically homogenous populations are used, spurious associations are unlikely to occur. We show that under small and realistic degrees of assortative mating over time, spurious associations arise even in ethnically homogeneous populations. We demonstrate that structured association and genomic control tests can, under certain conditions, correct for these spurious associations. We conclude that investigators should not assume spurious associations will not occur in association studies using ethnically homogenous populations and recommend the use of genomic control methods and/or family-based association tests within genetic association studies.

The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Publishing Authors By Initials

DT Redden,DB Allison,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Behavior genetics

VOLUME: 36

Page Numbers: 678-86

Journal Abbreviation: Behav. Genet.

ISSN: 0001-8244

DAY: 3

MONTH: Sep

YEAR: 2006

The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Information

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LANGUAGE: eng

NlmUniqueID: 251711

The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: physiology

Chemical & Substance for Abstract: The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture. Information

Substance Name: Genetic Markers

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Grant and Affiliation Information for The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture.

AFFILIATION: Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, USA. dredden@ms.soph.uab.edu

Country: United States

AGENCY: United States NCI

GRANT: U54CA100949

ACRONYM: CA

MEDLINETA: Behav Genet

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