[The effect of antisense human as RNA on activation induced apoptosis of T cell]

[The effect of antisense human as RNA on activation induced apoptosis of T cell] Research Abstract Details 

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[The effect of antisense human as RNA on activation induced apoptosis of T cell] Abstract Text:

Q Qian,M Wu,H Cao,Y Guo,S Fang,Z Qu,H Huang,Y Guo,

OBJECTIVE: To explore an approach to the reduction of activation induced apoptosis of T cell so as to maximize the number of CTL and enhance the tumor cytotoxicity. METHODS: CD3-induced Jurkat cell line was used as the activated T cell apoptosis model,and the antisense Fas cDNA was introduced into Jurkat cells with retroviral vector. RESULTS:The expression level of Fas protein in Jurkat cells transducted with the retroviral vector was decreased. Apoptosis was reduced in antisense Fas-transfected Jurkat cells after anti-CD3 or anti-Fas treatment. CONCLUSION: Antisense blocking of Fas expression can partially inhibit Jurkat cell apoptosis induced by anti-CD3 or anti Fas.

[The effect of antisense human as RNA on activation induced apoptosis of T cell] Publishing Authors By Initials

Q Qian,M Wu,H Cao,Y Guo,S Fang,Z Qu,H Huang,Y Guo,

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[The effect of antisense human as RNA on activation induced apoptosis of T cell] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 619-22

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 31

MONTH: Dec

YEAR: 1997

[The effect of antisense human as RNA on activation induced apoptosis of T cell] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Tumor Immunology and Gene Therapy Center, Eastern Institute of Hepatobiliary Surgery, Shanghai 200433.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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