The effect of acids on the survival of HIV during drug injection.

The effect of acids on the survival of HIV during drug injection. Research Abstract Details 

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The effect of acids on the survival of HIV during drug injection. Abstract Text:

Robert Heimer,Mark L Kinzly,Helen He,Nadia Abdala,

BACKGROUND: HIV epidemics around the world have been linked to injection drug use. In many instances, the injected drugs are acidic. HIV-1 is known to be labile to acids, but its susceptibility to acids in the conditions in which illicit drugs are injected is unknown. METHODS: We have combined data from ethnographic studies of injection drug use practices with laboratory virology to replicate and evaluate the effects of exposure to acids that are experienced during drug preparation and injection on HIV-1 viability. RESULTS: Short exposures to the acids significantly reduced the likelihood of recovering viable HIV-1 once pH is reduced to 2.3, but acidic solutions did not totally eliminate infectious HIV-1 that might contaminate syringes or solutions being injected, even at the lowest pH tested (pH 1.7). CONCLUSIONS: Acidification of drugs, which is required for dissolving free-base formulations of drugs, can significantly reduce but not eliminate the likelihood that syringes previously used by HIV-1-infected injection drug users infect the next injector. Methamphetamines, which are manufactured under extremely acidic pHs, are unlikely to harbor viable HIV if stored or sold in contaminated injection equipment.

The effect of acids on the survival of HIV during drug injection. Publishing Authors By Initials

R Heimer,ML Kinzly,H He,N Abdala,

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PUBMED ID PMID:

MEDLINE DATE:

The effect of acids on the survival of HIV during drug injection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of acquired immune deficiency syndromes (1

VOLUME: 45

Page Numbers: 144-50

Journal Abbreviation: J. Acquir. Immune Defic. Syndr

ISSN: 1525-4135

DAY: 1

MONTH: Jun

YEAR: 2007

The effect of acids on the survival of HIV during drug injection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892005

The effect of acids on the survival of HIV during drug injection. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: physiology

Chemical & Substance for Abstract: The effect of acids on the survival of HIV during drug injection. Information

Substance Name: Citric Acid

Registry Number: 77-92-9

Grant and Affiliation Information for The effect of acids on the survival of HIV during drug injection.

AFFILIATION: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA-14713

ACRONYM: DA

MEDLINETA: J Acquir Immune Defic Syndr

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