The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Abstract Text:

J S Baum,E Arama,H Steller,K McCall,J S Baum,E Arama,H Steller,K McCall,

Programmed cell death (PCD) in the Drosophila ovary occurs either during mid-oogenesis, resulting in degeneration of the entire egg chamber or during late oogenesis, to facilitate the development of the oocyte. PCD during oogenesis is regulated by mechanisms different from those that control cell death in other Drosophila tissues. We have analyzed the role of caspases in PCD of the female germline by examining caspase mutants and overexpressing caspase inhibitors. Imprecise P-element excision was used to generate mutants of the initiator caspase strica. While null mutants of strica or another initiator caspase, dronc, display no ovary phenotype, we find that strica exhibits redundancy with dronc, during both mid- and late oogenesis. Ovaries of double mutants contain defective mid-stage egg chambers similar to those reported previously in dcp-1 mutants, and mature egg chambers with persisting nurse cell nuclei. In addition, the effector caspases drice and dcp-1 also display redundant functions during late oogenesis, resulting in persisting nurse cell nuclei. These findings indicate that caspases are required for nurse cell death during mid-oogenesis, and participate in developmental nurse cell death during late oogenesis. This reveals a novel pathway of cell death in the ovary that utilizes strica, dronc, dcp-1 and drice, and importantly illustrates strong redundancy among the caspases.

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Publishing Authors By Initials

JS Baum,E Arama,H Steller,K McCall,JS Baum,E Arama,H Steller,K McCall,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 14

Page Numbers: 1508-17

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 27

MONTH: 04

YEAR: 2007

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9437445

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

AFFILIATION: Department of Biology, Graduate Program, Boston University, Boston, MA 02215, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM60574

ACRONYM: GM

MEDLINETA: Cell Death Differ

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis Related Publications

• A bizarre incident in sterility regime.
• Aldosterone in experimental and clinical medicine.
• An adaptive ERG technique to measure normal and altered dark adaptation in the mouse.
• CHILD HYGIENE: A NEW RAMIFICATION OF THE DENTAL PROBLEM.
• Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.
• Does a weight loss medicine make sense for obese type 2 diabetes? New information on endocannabinoid blockers.
• Effects of pain acceptance and pain control strategies on physical impairment in individuals with chronic low back pain.
• Electroconvulsive therapy: all in the family.
• Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance.
• Expecting the worst. How disaster management is taking the kidney community by storm.
• Extraperitoneal cesarean section in the profoundly infected patient.
• Imidacloprid plus Moxidectin to Prevent Heartworm Infection (Dirofilaria immitis) in Ferrets.
• Individual invention versus socio-ecological innovation: Unifying the behavioral and evolutionary sciences.
• Malocclusion as a risk factor in the etiology of headaches in children and adolescents.
• Noncanonical cell death pathways act during Drosophila oogenesis.
• Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete x-linked congenital stationary night blindness.
• Oral behaviors checklist: reliability of performance in targeted waking-state behaviors.
• Plasma progestogen levels in pregnant mares following administration of exogenous progesterone.
• Pseudocholinesterase deficiency and electroconvulsive therapy.
• Reversed-phase liquid chromatographic determination of meclozine in biological samples.
• Slipped upper femoral epiphysis: imaging of complications after treatment.
• Source of a problem with Fourier transform spectroscopy.
• Surgical complications of pregnancy.
• The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.
• The axon guidance gene lola is required for programmed cell death in the Drosophila ovary.
• The nasal mucosa in the laryngectomized patients.
• The role of itinerant teachers.
• The role of the cements in pedodontics.
• Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion.
• What constitutes successful dental practice?