The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis.

The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Research Abstract Details 

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The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Abstract Text:

Jianhua Zhu,Avnish Kapoor,Vaniyambadi V Sridhar,Fernanda Agius,Jian-Kang Zhu,

The Arabidopsis DNA glycosylase/lyase ROS1 participates in active DNA demethylation by a base-excision pathway. ROS1 has been shown to be required for demethylating a transgene promoter. To determine the function of ROS1 in demethylating endogenous loci, we carried out bisulfite-sequencing analysis of several transposons and other genes in the ros1 mutant. In the wild-type, although CpG sites at the majority of these loci are heavily methylated, many of the CpXpG and CpXpX sites have low levels of methylation or are not at all methylated. However, these CpXpG and CpXpX sites become heavily methylated in the ros1 mutant. Associated with this increased DNA methylation, these loci show decreased expression in the ros1 mutant. Our results suggest that active DNA demethylation is important in pruning the methylation patterns of the genome, and even the normally "silent" transposons are under dynamic control by both methylation and demethylation. This dynamic control may be important in keeping the plant epigenome plastic so that it can efficiently respond to developmental and environmental cues.

The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Publishing Authors By Initials

J Zhu,A Kapoor,VV Sridhar,F Agius,JK Zhu,

For similar proteins: nuclear proteins research abstracts see: proteins: nuclear proteins research

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The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 54-9

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 9

MONTH: Jan

YEAR: 2007

The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Information

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LANGUAGE: eng

NlmUniqueID: 9107782

The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Keywords Mesh Terms:

KEYWORDS: Nuclear Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis. Information

Substance Name: ROS1 protein, Arabidopsis

Registry Number: 0

Grant and Affiliation Information for The DNA glycosylase/lyase ROS1 functions in pruning DNA methylation patterns in Arabidopsis.

AFFILIATION: Center for Plant Cell Biology, Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01GM070795

ACRONYM: GM

MEDLINETA: Curr Biol

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