The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Abstract Text:

Daniel Kessler,Panagiotis Papatheodorou,Tina Stratmann,Elke Andrea Dian,Cristina Hartmann-Fatu,Joachim Rassow,Peter Bayer,Jonathan Wolf Mueller,

BACKGROUND: The parvulin-type peptidyl prolyl cis/trans isomerase Par14 is highly conserved in all metazoans. The recently identified parvulin Par17 contains an additional N-terminal domain whose occurrence and function was the focus of the present study. RESULTS: Based on the observation that the human genome encodes Par17, but bovine and rodent genomes do not, Par17 exon sequences from 10 different primate species were cloned and sequenced. Par17 is encoded in the genomes of Hominidae species including humans, but is absent from other mammalian species. In contrast to Par14, endogenous Par17 was found in mitochondrial and membrane fractions of human cell lysates. Fluorescence of EGFP fusions of Par17, but not Par14, co-localized with mitochondrial staining. Par14 and Par17 associated with isolated human, rat and yeast mitochondria at low salt concentrations, but only the Par17 mitochondrial association was resistant to higher salt concentrations. Par17 was imported into mitochondria in a time and membrane potential-dependent manner, where it reached the mitochondrial matrix. Moreover, Par17 was shown to bind to double-stranded DNA under physiological salt conditions. CONCLUSION: Taken together, the DNA binding parvulin Par17 is targeted to the mitochondrial matrix by the most recently evolved mitochondrial prepeptide known to date, thus adding a novel protein constituent to the mitochondrial proteome of Hominidae.

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Publishing Authors By Initials

D Kessler,P Papatheodorou,T Stratmann,EA Dian,C Hartmann-Fatu,J Rassow,P Bayer,JW Mueller,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BMC biology

VOLUME: 5

Page Numbers: 37

Journal Abbreviation: BMC Biol.

ISSN: 1741-7007

DAY: 17

MONTH: 09

YEAR: 2007

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101190720

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.

AFFILIATION: Department of Structural and Medicinal Biochemistry, Center for Medical Biotechnology - ZMB, University of Duisburg-Essen, 45117 Essen, Germany. daniel.kessler@uni-due.de

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: BMC Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae Related Publications

• A case report of Clarkson's disease: If you don't know it, you'll miss it.
• Algorithms for on-line Differentiation of Neuroelectric Activities.
• Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells.
• An open trial of levetiracetam for segmental and generalized dystonia.
• Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.
• Dosage in the treatment of pollinosis.
• Effect of footwear and orthotic devices on stress reduction and soft tissue strain of the neuropathic foot.
• Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity.
• Exercise training attenuates increases in lumbar sympathetic nerve activity produced by stimulation of the rostral ventrolateral medulla.
• Lattice-based volumetric global illumination.
• Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome.
• Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.
• Molecular recognition of BMP-2 and BMP receptor IA.
• Non-catalytic function for ATR in the checkpoint response.
• Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase.
• Numerical simulation of the plantar pressure distribution in the diabetic foot during the push-off stance.
• Oleamide synthesizing activity from rat kidney: identification as cytochrome c.
• On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements.
• Pioglitazone: an anti-diabetic compound with anti-aging properties.
• Real-time 3D computed tomographic reconstruction using commodity graphics hardware.
• TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases.
• The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.
• The amide rotational barrier in isonicotinamide: Dynamic NMR and ab initio studies.
• The experience of rural independent pharmacies with medicare part D: reports from the field.
• The risk of malarial infections and disease in Papua New Guinean children.
• The use of B-type natriuretic peptides in the intensive care unit.
• Trace element removal during in vitro and in vivo continuous haemodialysis.
• Transcriptional dysregulation during myeloid transformation in AML.
• Vaccines against malaria - an update.
• Virus infection causes specific learning deficits in honeybee foragers.