The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Abstract Text:

R Graham Robinett,Alex J Freemerman,Michael A Skinner,Lisa Shewchuk,Karen Lackey,R Graham Robinett,Alex J Freemerman,Michael A Skinner,Lisa Shewchuk,Karen Lackey,

Substituted 4-(3-hydroxyanilino)-quinoline compounds, initially identified as small-molecule inhibitors of src family kinases, have been evaluated as potential inhibitors of RET kinase. Three compounds, 38, 31, and 40, had K(i)'s of 3, 25, and 50 nM in an in vitro kinase assay; while a cell based kinase assay showed K(i)'s of 300, 100, and 45 nM, respectively. These compounds represent potential new leads for the treatment of medullary and papillary thyroid cancer.

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Publishing Authors By Initials

R Graham Robinett,AJ Freemerman,MA Skinner,L Shewchuk,K Lackey,R Graham Robinett,AJ Freemerman,MA Skinner,L Shewchuk,K Lackey,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5886-93

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 25

MONTH: 08

YEAR: 2007

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.

AFFILIATION: GlaxoSmithKline, Molecular Discovery Research Chemistry, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The discovery of substituted 4-3-hydroxyanilino-quinolines as potent RET kinase inhibitors Related Publications

• "Feeling blue" in Spanish: A qualitative inquiry of depression among Mexican immigrants.
• Adjusting to patients' increasing financial responsibility.
• Biology of sewage treatment.
• Effectiveness of endovenous laser treatment in eliminating superficial venous reflux.
• Enzymatic activities of isolated amelanotic and melanotic granules of mouse melanomas and suggested relationship to mitochondria.
• Failure of oral saccharine to influence blood sugar.
• How to evacuate a psychiatric hospital: a Hurricane Katrina success story.
• Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors.
• Observations on the acute and chronic toxicity of toxaphene in the dog.
• Observations on the percutaneous absorption of toxaphene in the rabbit and the dog.
• The constituents of Sierra juniper wood, Juniperus occidentalis, Hooker.
• The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.
• Transient hypotension following rapid intravenous injections of hypertonic solutions.