The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium.

The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium. Research Abstract Details 

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The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium. Abstract Text:

Silvia Zecchini,Marco Bianchi,Nicoletta Colombo,Roberta Fasani,Giovanni Goisis,Chiara Casadio,Giuseppe Viale,Jinsong Liu,Meenhard Herlyn,Andrew K Godwin,Paolo G Nuciforo,Ugo Cavallaro,Silvia Zecchini,Marco Bianchi,Nicoletta Colombo,Roberta Fasani,Giovanni Goisis,Chiara Casadio,Giuseppe Viale,Jinsong Liu,Meenhard Herlyn,Andrew K Godwin,Paolo G Nuciforo,Ugo Cavallaro,

Epithelial ovarian carcinoma (EOC) arises from the ovarian surface epithelium (OSE), a monolayer of poorly differentiated epithelial cells that lines the ovary. The molecular mechanisms underlying EOC invasion into the surrounding stroma and dissemination to the peritoneum and to retroperitoneal lymph nodes are still unclear. Here, we analyzed the expression and the functional role of the cell adhesion molecule L1 during EOC development. In patient-derived samples, L1 was expressed both in OSE and in a subset of EOC, in the latter being mostly restricted to the invasive areas of the tumors. The expression of L1 correlated significantly with poor outcome and with unfavorable clinicopathologic features of the disease. The peculiar expression pattern of L1 in normal OSE and invasive EOC raised the possibility that this adhesion molecule serves a different function in nontransformed versus neoplastic ovarian epithelial cells. Indeed, we showed that in OSE cells L1 supports cell-cell adhesion and enhances apoptosis, whereas it has no effect on cell proliferation and invasion. In contrast, L1 inhibits cell-cell adhesion and apoptosis in ovarian carcinoma cells, where it promotes malignancy-related properties, such as cell proliferation, Erk1/2-dependent and phosphoinositide 3-kinase-dependent invasion, and transendothelial migration. Interestingly, a crosstalk with the fibroblast growth factor receptor signaling is implicated in the promalignant function of L1 in tumor cells. Our findings point to L1 as an EOC biomarker correlating with poor prognosis, and highlight a switch in L1 function associated to the neoplastic transformation of ovarian epithelial cells, thus implicating L1 as a potential therapeutic target. [Cancer Res 2008;68(4):1110-8].

The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium. Publishing Authors By Initials

S Zecchini,M Bianchi,N Colombo,R Fasani,G Goisis,C Casadio,G Viale,J Liu,M Herlyn,AK Godwin,PG Nuciforo,U Cavallaro,S Zecchini,M Bianchi,N Colombo,R Fasani,G Goisis,C Casadio,G Viale,J Liu,M Herlyn,AK Godwin,PG Nuciforo,U Cavallaro,

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The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer research

VOLUME: 68

Page Numbers: 1110-8

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 15

MONTH: Feb

YEAR: 2008

The differential role of l1 in ovarian carcinoma and normal ovarian surface epithelium. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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AFFILIATION: FIRC Institute of Molecular Oncology, European Institute of Oncology, and University of Milano School of Medicine, Milano, Italy.

Country: United States

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MEDLINETA: Cancer Res

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