The dexamethasone suppression and metyrapone tests in depression.

The dexamethasone suppression and metyrapone tests in depression. Research Abstract Details 

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The dexamethasone suppression and metyrapone tests in depression. Abstract Text:

The dexamethasone suppression test (DST) and the metyrapone test (MT), a useful and reliable procedure for assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, were performed in 28 patients suffering from major depressive illness with melancholia. The relationship between the DST and MT appeared to be complex. Patients who failed to suppress cortisol secretion after dexamethasone administration had higher postmetyrapone cortexolone levels and cortexolone/cortisol ratios than suppressors. However, there was a wide range of metyrapone responses in patients exhibiting abnormal DST results. This suggests that failure of adequate suppression after 1 mg of dexamethasone in depressed patients does not necessarily reflect homogeneity in the HPA axis disturbances of such patients.

The dexamethasone suppression and metyrapone tests in depression. Publishing Authors By Initials

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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The dexamethasone suppression and metyrapone tests in depression. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Psychiatry research

VOLUME: 15

Page Numbers: 153-8

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Jun

YEAR: 1985

The dexamethasone suppression and metyrapone tests in depression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911385

The dexamethasone suppression and metyrapone tests in depression. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: physiopathology

Chemical & Substance for Abstract: The dexamethasone suppression and metyrapone tests in depression. Information

Substance Name: Metyrapone

Registry Number: 54-36-4

Grant and Affiliation Information for The dexamethasone suppression and metyrapone tests in depression.

AFFILIATION:

Country: NETHERLANDS

AGENCY: United States NCRR

GRANT: 2507RR0540021

ACRONYM: RR

MEDLINETA: Psychiatry Res

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