The development of oral liquid dosage forms of metronidazole.

The development of oral liquid dosage forms of metronidazole. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The development of oral liquid dosage forms of metronidazole. Abstract Text:

The stability of eight samples of metronidazole in aqueous vehicles was studied using a modified HPLC assay method. The samples were prepared using either metronidazole powder (5 mg/ml), metronidazole hydrochloride injection powder (10 mg/ml), or metronidazole powdered tablets (10 mg/ml). The samples prepared using metronidazole hydrochloride powder were stable and clear for at least 133 days at 25 degrees C. Their pH values were between 1.8 and 2.0. The samples prepared from metronidazole powder had pH values close to neutral and were stable for at least 45 days at room temperature (25 degrees C). However, to keep the drug in solution, the concentration of metronidazole powder was reduced to 5 mg/ml. The powdered tablets did not yield good uniform suspensions.

The development of oral liquid dosage forms of metronidazole. Publishing Authors By Initials

For similar pharmaceutical preparations: solutions research abstracts see: pharmaceutical preparations: solutions research

PUBMED ID PMID:

MEDLINE DATE:

The development of oral liquid dosage forms of metronidazole. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 18

Page Numbers: 291-4

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Aug

YEAR: 1993

The development of oral liquid dosage forms of metronidazole. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704308

The development of oral liquid dosage forms of metronidazole. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: chemistry

Chemical & Substance for Abstract: The development of oral liquid dosage forms of metronidazole. Information

Substance Name: Metronidazole

Registry Number: 443-48-1

Grant and Affiliation Information for The development of oral liquid dosage forms of metronidazole.

AFFILIATION: Department of Pharmaceutics, University of Houston, TX 77030.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Pharm Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The development of oral liquid dosage forms of metronidazole Related Publications

• Advances in therapeutics.
• Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice.
• Building bridges.
• Cancer resources in North Carolina.
• Chemical stabilities of famotidine and ranitidine hydrochloride in intravenous admixtures.
• Corticotropin-releasing hormone and pro-opiomelanocortin gene expression in female monkeys with differences in sensitivity to stress.
• Development of a stable oral liquid dosage form of spironolactone.
• Hypothalamic gonadotrophin-releasing hormone expression in female monkeys with different sensitivity to stress.
• INTEGRIS Baptist Medical Center: transparency and returnship take quality to the community.
• Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques.
• Oestrogen receptor Beta contributes to the transient sex difference in tyrosine hydroxylase expression in the mouse locus coeruleus.
• Physical violence during pregnancy: maternal complications and birth outcomes.
• Saddle block spinal anesthesia in obstetrics, with special reference to the use of metycaine.
• Serotonin in microdialysate from the mediobasal hypothalamus increases after progesterone administration to estrogen primed macaques.
• Stability of acyclovir sodium in dextrose and sodium chloride injections.
• Stability of captopril in some aqueous systems.
• Stability of foscarnet sodium in 5% dextrose and 0.9% sodium chloride injections.
• Stability of metronidazole benzoate in suspensions.
• Stability of metronidazole in solutions and suspensions.
• Stability of piperacillin sodium in the presence of tazobactam sodium in 5% dextrose and normal saline injections.
• The development of oral liquid dosage forms of metronidazole.
• The treatment of burns.
• Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice.
• Two independent measurements of debye lengths in doped nonpolar liquids.
• Unique responses of midbrain CART neurons in macaques to ovarian steroids.