The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications.

The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Research Abstract Details 

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The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Abstract Text:

D Armanini,U Kuhnle,H Witzgall,U Tietze,H Saule,C Schroeter,T Strasser,I Butenandt,F Bidlingmaier,P C Weber,

The affinity and the capacity of mineralocorticoid receptors (MR) in human mononuclear leukocytes (HML) were determined in 9 patients with Conn's syndrome (PA) and in 3 patients with pseudohypoaldosteronism (PHA). The number of binding sites per cell was 136 +/- 39 (mean +/- SD) in PA. One case with PHA had no MR, and of the other 2 patients, one had 50 and the other 55 receptors per cell. The capacity of normal controls ranged from 200 to 400 receptors per cell (n = 20). We conclude that the etiology of PHA is due to a lack of MR in the target tissues and that a down regulation of MR may exist in PA.

The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Publishing Authors By Initials

D Armanini,U Kuhnle,H Witzgall,U Tietze,H Saule,C Schroeter,T Strasser,I Butenandt,F Bidlingmaier,PC Weber,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, steroid research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, steroid research

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The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 8

Page Numbers: 781-5

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1986

The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Keywords Mesh Terms:

KEYWORDS: Receptors, Steroid

MESH TERMS: metabolism

Chemical & Substance for Abstract: The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications. Information

Substance Name: Aldosterone

Registry Number: 52-39-1

Grant and Affiliation Information for The determination of mineralocorticoid receptors in human mononuclear leukocytes from patients with mineralocorticoid excess: physiological and pathological implications.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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