The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis.

The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. Research Abstract Details 

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The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. Abstract Text:

Marta Martins,Miguel Viveiros,Jette E Kristiansen,Joseph Molnar,Leonard Amaral,Marta Martins,Miguel Viveiros,Jette E Kristiansen,Joseph Molnar,Leonard Amaral,

BACKGROUND: The aim of the study was to evaluate the effectiveness of thioridazine (TZ) at different dose levels on mice that had been infected intraperitoneally (i.p.) with a high dose of the Mycobacterium tuberculosis ATCC H37Rv strain. SUBJECTS AND METHODS: Groups of five female BALB/C mice were infected i.p. with 10(6) colony forming units/mL. After thirty days, treatment with TZ was initiated, except for the control group. Mice were treated with TZ at equivalent concentrations to that used in the humans (1200 mg/day), ranging from 0.05 to 0.5 mg/day. RESULTS: The results demonstrated that a daily dose of 0.5 mg/day of TZ reduced the number of colony forming units retrieved from the lungs of infected mice within one month. CONCLUSION: By the end of 300 days of therapy, although mycobacteria were still retained their presence, in comparison to that of the control was 8 orders of magnitude lower.

The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. Publishing Authors By Initials

M Martins,M Viveiros,JE Kristiansen,J Molnar,L Amaral,M Martins,M Viveiros,JE Kristiansen,J Molnar,L Amaral,

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The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: In vivo (Athens, Greece)

VOLUME: 21

Page Numbers: 771-5

Journal Abbreviation: In Vivo

ISSN: 0258-851X

DAY: 16

MONTH: 11

YEAR: 2007

The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. Information

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LANGUAGE: eng

NlmUniqueID: 8806809

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AFFILIATION: Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisboa, Portugal.

Country: Greece

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