The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy.

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Abstract Text:

J W Mosley,E A Operskalski,L H Tobler,Z J Buskell,W W Andrews,B Phelps,J Dockter,C Giachetti,L B Seeff,M P Busch, ,

Knowing the likely distribution of intervals from hepatitis C infection to first RNA-negativity is important in deciding about therapeutic intervention. Prospectively collected sera and data from the Transfusion-transmitted Viruses Study (1974-1980) provide specific dates of infection and pattern of alanine aminotransferase (ALT) elevations. We examined frequency, timing and correlates of spontaneous resolution for 94 acutely infected transfusion recipients followed for a median of 9.5 months. Later, follow-up sera (>10 years) were available for 27 of the 94 cases from a Veterans Administration (VA) Study (1989-1990). Twenty-five (27%) of the 94 cases were classified as probably resolved during the episode itself. First RNA negativity occurred at 6-50 weeks (median, 19.5 weeks) after infection, and 5-43 weeks (median, 11 weeks) after ALT elevation. Thirteen of the 25 cases remained RNA-negative subsequently; 12 others had 1-6 RNA-positive sera intercalated between first and last RNA-negative results. RNA negativity, therefore, began variably and was interrupted in 12 cases of 25 (48%) by transient RNA-positive sera. Five of these 25 patients who were RNA-negative in the last study specimen had late, Veterans Administration Study follow-up; none showed viraemia. Of the remaining 69 transfusion transmitted virus study recipients, whose last serum was RNA-positive, two cleared viraemia after the last study serum but before late follow-up. Eleven (16%) had 23 intercalated RNA-negative sera before last positivity. RNA status, therefore, needs monitoring for many months before judging the spontaneous outcome as transient negativity may occur. Resolution was significantly more common in women and symptomatic cases; it was not associated with viral load in the infectious donation, HCV genotype, or the recipient's age.

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Publishing Authors By Initials

JW Mosley,EA Operskalski,LH Tobler,ZJ Buskell,WW Andrews,B Phelps,J Dockter,C Giachetti,LB Seeff,MP Busch, ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of viral hepatitis

VOLUME: 15

Page Numbers: 120-8

Journal Abbreviation: J. Viral Hepat.

ISSN: 1352-0504

DAY: 10

MONTH: Feb

YEAR: 2008

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9435672

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy.

AFFILIATION: Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Viral Hepat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy Related Publications

• Antibodies to a novel antigen in acute hepatitis C virus infections.
• Defining correlates of T cell protection against infection.
• Determination of the enantiomeric composition of guest molecules by chemometric analysis of the UV-visible spectra of cyclodextrin guest-host complexes.
• Do state parity laws reduce the financial burden on families of children with mental health care needs?
• Effect of photosensitizer dose on fluence rate responses to photodynamic therapy.
• Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms.
• Improving survival in acute lung injury: is there a role for treatment bundles?
• Inhalation of the ETA receptor antagonist LU-135252 selectively attenuates hypoxic pulmonary vasoconstriction.
• Leukoreduction of blood transfusions does not diminish transfusion-associated microchimerism in trauma patients.
• Local physiological changes during photodynamic therapy.
• Off-label use of exenatide for the management of insulin-resistant type 1 diabetes mellitus in an obese patient with human immunodeficiency virus infection.
• Olefin oxygenation by the hydroperoxide adduct of a nonheme manganese(IV) complex: epoxidations by a metallo-peracid produces gentle selective oxidations.
• One target-multiple indications: a call for an integrated common mechanisms strategy.
• Origin of CD8+ Effector and Memory T Cell Subsets.
• Persistence of West Nile virus-specific antibodies in viremic blood donors.
• Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy.
• Prevalence and quantitation of parvovirus B19 DNA levels in blood donors with a sensitive polymerase chain reaction screening assay.
• Reply.
• Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates.
• The course of hepatitis C viraemia in transfusion recipients prior to availability of antiviral therapy.
• The neuronal dynamics underlying cognitive flexibility in set shifting tasks.
• The utility of oral diabetes medications in type 2 diabetes of the young.
• Transfusion-associated microchimerism.
• Transfusion-associated microchimerism: a new complication of blood transfusions in severely injured patients.
• Unique functions of splenic CD8alpha+ dendritic cells during infection with intracellular pathogens.
• [Female genital actinomycosis]
• [In Process Citation]
• [Prediction of spontaneous abortion by vaginal cytologic smears (author's transl)i1]
• [Problems of corticoid therapy in pregnancy]
• [The effects of metacresol sulfonic acid on defects and inflammations of the genital mucosa.]