The cough reflex in animals: relevance to human cough research.

The cough reflex in animals: relevance to human cough research. Research Abstract Details 

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The cough reflex in animals: relevance to human cough research. Abstract Text:

All mammalian species studied cough or display some similar respiratory reflex upon aerosol challenge with tussigenic stimuli such as citric acid or capsaicin. Animals cough to the same stimuli that evoke coughing in humans, and therapeutic agents that display antitussive effects in human studies also prevent coughing in animals. The many invasive procedures and complementary in vitro studies possible in animals but not readily reproduced in human subjects, along with the proven predictive value of cough studies in animals, provide the rationale for animal modeling of human cough. The advantages and disadvantages of studying cough in animals are discussed.

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The cough reflex in animals: relevance to human cough research. Journal Published:

PUBLICATION TYPE: Review

Journal: Lung

VOLUME: 186 Suppl 1

Page Numbers: S23-8

Journal Abbreviation: Lung

ISSN: 0341-2040

DAY: 15

MONTH: 12

YEAR: 2007

The cough reflex in animals: relevance to human cough research. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 7701875

The cough reflex in animals: relevance to human cough research. Keywords Mesh Terms:

KEYWORDS: Reflex

MESH TERMS: physiology

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Grant and Affiliation Information for The cough reflex in animals: relevance to human cough research.

AFFILIATION: Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. bjc@jhmi.edu

Country: United States

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MEDLINETA: Lung

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