The complications of promiscuity: endocannabinoid action and metabolism.

The complications of promiscuity: endocannabinoid action and metabolism. Research Abstract Details 

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The complications of promiscuity: endocannabinoid action and metabolism. Abstract Text:

S P H Alexander,D A Kendall,

In this review, we present our understanding of the action and metabolism of endocannabinoids and related endogenous molecules. It is clear that the interactions between the multiple endocannabinoid-like molecules (ECLs) are highly complex, both at the level of signal transduction and metabolism. Thus, ECLs are a group of ligands active at 7-transmembrane and nuclear receptors, as well as transmitter-gated and ion channels. ECLs and their metabolites can converge on common endpoints (either metabolic or signalling) through contradictory or reinforcing pathways. We highlight the complexity of the endocannabinoid system, based on the promiscuous nature of ECLs and their metabolites, as well as the synthetic modulators of the endocannabinoid system.

The complications of promiscuity: endocannabinoid action and metabolism. Publishing Authors By Initials

SP Alexander,DA Kendall,

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The complications of promiscuity: endocannabinoid action and metabolism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of pharmacology

VOLUME: 152

Page Numbers: 602-23

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 17

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7502536

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AFFILIATION: School of Biomedical Sciences and Institute of Neuroscience, University of Nottingham Medical School, Nottingham NG7 7LP, UK. steve.alexander@nottingham.ac.uk

Country: England

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Br J Pharmacol

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