The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Research Abstract Details 

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The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Abstract Text:

A E Eckhardt,C S Timpte,A W DeLuca,R L Hill,

The complete structure of the DNA encoding the polypeptide chain of porcine submaxillary mucin has been determined. The polypeptide is composed of distinct domains. A large central domain containing tandem repeats of 81 residues each is flanked by much shorter domains with sequences similar to the tandem repeats. Four disulfide-rich domains, three at the amino terminus and one at the carboxyl terminus, complete the chain. The disulfide-rich domains have significant sequence identity to those of other mucins and prepro-von Willebrand factor. The coding region of the mucin gene is highly polymorphic, and three alleles were identified in a single animal that encoded different numbers of the 81-residue tandem repeats. A single large exon devoid of introns encodes the tandem repeat domains. The largest allele with 135 tandem repeats encoded 13,288 amino acids to give a polypeptide with Mr = 1,184,106. The other two alleles contained 99 and 125 tandem repeats, respectively. Each allele also showed different restriction fragment length polymorphisms, which is consistent with the different patterns seen in individual animals. Fragment length polymorphism was also seen within two different families of animals, indicating that the polymorphism observed occurs in a single generation.

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Publishing Authors By Initials

AE Eckhardt,CS Timpte,AW DeLuca,RL Hill,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

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The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of biological chemistry

VOLUME: 272

Page Numbers: 33204-10

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 26

MONTH: Dec

YEAR: 1997

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: chemistry

Chemical & Substance for Abstract: The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin. Information

Substance Name: Mucins

Registry Number: 0

Grant and Affiliation Information for The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

AFFILIATION: Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

Country: UNITED STATES

AGENCY: United States PHS

GRANT: 25766

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MEDLINETA: J Biol Chem

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