The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.

The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Research Abstract Details 

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The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Abstract Text:

Rebecca B Blank,Erika W Lamb,Anna S Tocheva,Emily T Crow,K C Lim,James H McKerrow,Stephen J Davies,

The human pathogen Schistosoma mansoni exhibits a highly evolved and intricate relationship with its host, evading immune destruction while co-opting CD4(+) T cell-driven mechanisms to facilitate parasite development and egg excretion. Because the common gamma ( gamma (c)) chain cytokine interleukin (IL)-7 is also implicated in modulating schistosome development, we investigated whether this effect is mediated indirectly through the essential role that IL-7 plays in CD4(+) T cell growth and survival. We demonstrate that attenuated schistosome development in the absence of IL-7 results from dysregulated T cell homeostasis and not from disruption of direct interactions between schistosomes and IL-7. We also identify an indirect role that another gamma (c) chain cytokine plays in schistosome development, demonstrating that IL-2 expression by CD4(+) T cells is essential for normal parasite development. Thus, cytokines critical for CD4(+) T cell survival and function can mediate indirect but potent effects on developing schistosomes and underscore the importance of CD4(+) T cells in facilitating schistosome development.

The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Publishing Authors By Initials

RB Blank,EW Lamb,AS Tocheva,ET Crow,KC Lim,JH McKerrow,SJ Davies,

For similar parasitic diseases: helminthiasis: trematode infections: schistosomiasis: schistosomiasis mansoni research abstracts see: parasitic diseases: helminthiasis: trematode infections: schistosomiasis: schistosomiasis mansoni research

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The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 194

Page Numbers: 1609-16

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 23

MONTH: 10

YEAR: 2006

The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Information

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LANGUAGE: eng

NlmUniqueID: 413675

The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Keywords Mesh Terms:

KEYWORDS: Schistosomiasis mansoni

MESH TERMS: parasitology

Chemical & Substance for Abstract: The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. Information

Substance Name: Receptors, Interleukin-7

Registry Number: 0

Grant and Affiliation Information for The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.

AFFILIATION: Tropical Disease Research Unit, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI066227

ACRONYM: AI

MEDLINETA: J Infect Dis

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