The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Research Abstract Details 

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The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Abstract Text:

Loning Fu,Helene Pelicano,Jinsong Liu,Peng Huang,Cheng Lee,

The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After gamma radiation, these mice show a marked increase in tumor development and reduced apoptosis in thymocytes. The core circadian genes are induced by gamma radiation in wild-type mice but not in mPer2 mutant mice. Temporal expression of genes involved in cell cycle regulation and tumor suppression, such as Cyclin D1, Cyclin A, Mdm-2, and Gadd45alpha, is deregulated in mPer2 mutant mice. In particular, the transcription of c-myc is controlled directly by circadian regulators and is deregulated in the mPer2 mutant. Our studies suggest that the mPer2 gene functions in tumor suppression by regulating DNA damage-responsive pathways.

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Publishing Authors By Initials

L Fu,H Pelicano,J Liu,P Huang,C Lee,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 111

Page Numbers: 41-50

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 4

MONTH: Oct

YEAR: 2002

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 413066

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: genetics

Chemical & Substance for Abstract: The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Information

Substance Name: Proto-Oncogene Proteins c-mdm2

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.

AFFILIATION: Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Country: United States

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MEDLINETA: Cell

REFSOURCE: Cell 2002 Dec 27;111(7):1055

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