The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Research Abstract Details 

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The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Abstract Text:

Mariko Kashiwagi,Bruce A Morgan,Katia Georgopoulos,

Using conditional gene targeting in mice, we show that the chromatin remodeler Mi-2beta is crucial for different aspects of skin development. Early (E10.5) depletion of Mi-2beta in the developing ventral epidermis results in the delayed reduction of its suprabasal layers in late embryogenesis and to the ultimate depletion of its basal layer. Later (E13.5) loss of Mi-2beta in the dorsal epidermis does not interfere with suprabasal layer differentiation or maintenance of the basal layer, but induction of hair follicles is blocked. After initiation of the follicle, some subsequent morphogenesis of the hair peg may proceed in the absence of Mi-2beta, but production of the progenitors that give rise to the inner layers of the hair follicle and hair shaft is impaired. These results suggest that the extended self-renewal capacity of epidermal precursors arises early during embryogenesis by a process that is critically dependent on Mi-2beta. Once this process is complete, Mi-2beta is apparently dispensable for the maintenance of established repopulating epidermal stem cells and for the differentiation of their progeny into interfollicular epidermis for the remainder of gestation. Mi-2beta is however essential for the reprogramming of basal cells to the follicular and, subsequently, hair matrix fates.

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Publishing Authors By Initials

M Kashiwagi,BA Morgan,K Georgopoulos,

For similar cells: stem cells research abstracts see: cells: stem cells research

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The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 1571-82

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 14

MONTH: 03

YEAR: 2007

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: cytology

Chemical & Substance for Abstract: The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Information

Substance Name: Mi-2beta protein, mouse

Registry Number: EC 3.6.1.3

Grant and Affiliation Information for The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

AFFILIATION: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Country: England

AGENCY: United States NIAID

GRANT: R01 AI380342

ACRONYM: AI

MEDLINETA: Development

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