The challenge of Down syndrome.

The challenge of Down syndrome. Research Abstract Details 

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The challenge of Down syndrome. Abstract Text:

Stylianos E Antonarakis,Charles J Epstein,

Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is only recently that there has been hope for the possibility to understand its pathogenesis and to use this information to devise approaches for the prevention and treatment of its numerous features. The earlier pessimism was due to several reasons, including: (i) the nature of the genetic defect that leads to the syndrome; (ii) the multiplicity of systems involved; and (iii) the high degree of variability of the phenotype. However, science has now caught up with the problem, and recent developments, especially in genetics, genomics, developmental biology and neuroscience, suggest that these potential impediments might not be as arduous as once appeared. As a result, basic research on DS is now rapidly accelerating, and there is hope that the findings will be translatable into benefit for people with DS.

The challenge of Down syndrome. Publishing Authors By Initials

SE Antonarakis,CJ Epstein,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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The challenge of Down syndrome. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in molecular medicine

VOLUME: 12

Page Numbers: 473-9

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ISSN: 1471-4914

DAY: 28

MONTH: 08

YEAR: 2006

The challenge of Down syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 100966035

The challenge of Down syndrome. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: physiopathology

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Grant and Affiliation Information for The challenge of Down syndrome.

AFFILIATION: Department of Genetic Medicine and Development, University of Geneva Medical School, University Hospitals of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland.

Country: England

AGENCY: United States NICHD

GRANT: HD 31498

ACRONYM: HD

MEDLINETA: Trends Mol Med

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