The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication.

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Research Abstract Details 

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The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Abstract Text:

Shomita S Mathew,Eileen Bridge,

Adenovirus type 5 (Ad5) relocalizes and degrades the host DNA repair protein Mre11, and efficiently initiates viral DNA replication. Mre11 associates with Ad E4 mutant DNA replication centers and is important for concatenating viral genomes. We have investigated the role of Mre11 in the E4 mutant DNA replication defect. RNAi-mediated knockdown of Mre11 dramatically rescues E4 mutant DNA replication in cells that do or do not concatenate viral genomes, suggesting that Mre11 inhibits DNA replication independent of genome concatenation. The mediator of DNA damage checkpoint 1 (Mdc1) protein is involved in recruiting and sustaining Mre11 at sites of DNA damage following ionizing radiation. We observe foci formation by Mdc1 in response to viral infection, indicating that this damage response protein is activated. However, knockdown of Mdc1 does not prevent Mre11 from localizing at viral DNA replication foci or rescue E4 mutant DNA replication. Our results are consistent with a model in which Mre11 interferes with DNA replication when it is localized at viral DNA replication foci.

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Publishing Authors By Initials

SS Mathew,E Bridge,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

PUBMED ID PMID:

MEDLINE DATE:

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 365

Page Numbers: 346-55

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 2

MONTH: 05

YEAR: 2007

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Information

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LANGUAGE: eng

NlmUniqueID: 110674

The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: genetics

Chemical & Substance for Abstract: The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Information

Substance Name: Trans-Activators

Registry Number: 0

Grant and Affiliation Information for The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication.

AFFILIATION: Department of Microbiology, 32 Pearson Hall, Miami University, Oxford OH 45056, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA82111

ACRONYM: CA

MEDLINETA: Virology

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