The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Research Abstract Details 

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The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Abstract Text:

James A Flanders,Qiyu Feng,Shubha Bagrodia,Maria T Laux,Avinash Singavarapu,Richard A Cerione,

Members of the Cool protein family contain SH3, Dbl, and pleckstrin homology domains and are binding partners for the p21-activated kinase (PAK). Using the yeast two-hybrid screen, we identified Cbl-b as a Cool family binding partner. We co-immunoprecipitated endogenous Cool and Cbl-b from a variety of breast cancer cell lines. The Cool-Cbl-b interaction requires the SH3 domain of Cool and competes with the binding of PAK to Cool proteins. Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, thus providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation.

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Publishing Authors By Initials

JA Flanders,Q Feng,S Bagrodia,MT Laux,A Singavarapu,RA Cerione,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary: protein interaction domains and motifs: src homology domains research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary: protein interaction domains and motifs: src homology domains research

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The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: FEBS letters

VOLUME: 550

Page Numbers: 119-23

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 28

MONTH: Aug

YEAR: 2003

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 155157

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Keywords Mesh Terms:

KEYWORDS: src Homology Domains

MESH TERMS: physiology

Chemical & Substance for Abstract: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. Information

Substance Name: Ubiquitin-Protein Ligases

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

AFFILIATION: Department of Molecular Medicine, Baker Laboratory, Cornell University, Veterinary Medical Center, Ithaca, NY 14853, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM47458

ACRONYM: GM

MEDLINETA: FEBS Lett

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