The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Abstract Text:

Yunfei Huang,Bingnan N Kang,Jing Tian,Yi Liu,Hongbo R Luo,Lynda Hester,Solomon H Snyder,

Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3. Depletion of CAT1 and CAT3 by RNA interference blocks influences of NMDA receptor activation on the mTOR pathway and neuronal process formation. Thus, the CATs mediate influences of NMDA receptor activation on the mTOR pathway that regulates neuronal processes.

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Publishing Authors By Initials

Y Huang,BN Kang,J Tian,Y Liu,HR Luo,L Hester,SH Snyder,

For similar proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpv cation channels research abstracts see: proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpv cation channels research

PUBMED ID PMID:

MEDLINE DATE:

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 449-58

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 17

MONTH: Jan

YEAR: 2007

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Keywords Mesh Terms:

KEYWORDS: TRPV Cation Channels

MESH TERMS: metabolism

Chemical & Substance for Abstract: The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Information

Substance Name: Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.

AFFILIATION: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH-18501

ACRONYM: MH

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway Related Publications

• 11-Beta hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids.
• Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.
• Cancer risk assessment: examining the family physician's role.
• Contaminant exposures at the 4H shell mounds in the Santa Barbara Channel.
• Exploring Common Ground in the Stem Cell Ethical Debate-A Perspective for Scientists: Introduction to this Special Issue of Stem Cell Reviews.
• Fluence rate as a modulator of PDT mechanisms.
• From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.
• Galectin-1 in secondary alveolar septae of neonatal mouse lung.
• Inositol pyrophosphate pyrotechnics.
• Large animal models are critical for rationally advancing regenerative therapies.
• Mapping of transcription factor binding regions in mammalian cells by ChIP: comparison of array- and sequencing-based technologies.
• Modeling laser beam diffraction and propagation by the mode-expansion method.
• Moving GLM ballistocardiogram artifact reduction for EEG acquired simultaneously with fMRI.
• Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.
• New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.
• Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.
• Nitric oxide-GAPDH-Siah: a novel cell death cascade.
• Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation.
• Protein microarray technology.
• Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives.
• Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol.
• Response to Beecher's comment to The Scientist.
• Spatiotemporal population distributions and their implications for species coexistence in a variable environment.
• Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
• Subthreshold microstimulation in frontal eye fields updates spatial memories.
• Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations.
• The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.
• The importance of screening for intimate partner violence (IPV).
• The microtubule-pore gatekeeper.
• What is a gene, post-ENCODE? History and updated definition.