The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.

The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Research Abstract Details 

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The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Abstract Text:

Masamitsu Tanaka,Kazuki Sasaki,Reiko Kamata,Ryuichi Sakai,

Interaction of the Eph family of receptor protein tyrosine kinases and their ligands, ephrin family members, induces bi-directional signaling via cell-cell contacts. High expression of B-type ephrin is associated with high invasion potential of tumors, however, the mechanism by which ephrin-B promotes cancer cell invasion is poorly understood. We show that interaction of ephrin-B1 with the Eph receptor B2 (EphB2) significantly enhances processing of the extracellular domain of ephrin-B1, which is regulated by the C-terminus. Matrix metalloproteinase-8 (MMP-8) is the key protease that cleaves ephrin-B1, and the C-terminus of ephrin-B1 regulates activation of the extracellular release of MMP-8 without requirement of de novo protein synthesis. One possible mechanism by which ephrin-B1 regulates the exocytosis of MMP-8 is the activation of Arf1 GTPase, a critical regulator of membrane trafficking. In support of this hypothesis, activation of ephrin-B1 increased GTP-bound Arf1, and the secretion of MMP-8 was reduced by expression of a dominant-negative mutant of Arf1. Expression of ephrin-B1 promoted the invasion of cancer cells in vivo, which required the C-terminus of ephrin-B1. Our results suggest a novel function of the C-terminus of ephrin-B1 in activating MMP-8 secretion, which promotes the invasion of cancer cells.

The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Publishing Authors By Initials

M Tanaka,K Sasaki,R Kamata,R Sakai,

For similar cells: cells, cultured: cell line: cell line, tumor: u937 cells research abstracts see: cells: cells, cultured: cell line: cell line, tumor: u937 cells research

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The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 2179-89

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 13

MONTH: 06

YEAR: 2007

The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 52457

The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Keywords Mesh Terms:

KEYWORDS: U937 Cells

MESH TERMS: genetics

Chemical & Substance for Abstract: The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. Information

Substance Name: ADP-Ribosylation Factor 1

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.

AFFILIATION: Department of Growth Factor Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Tokyo 104-0045, Japan.

Country: England

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MEDLINETA: J Cell Sci

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