The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival.

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Abstract Text:

Saeyoull Cho,Katherine W Rogers,David S Fay,

BACKGROUND: The mammalian glycopeptide hormone receptors (GPHRs) are key regulators of reproductive development, and their homologs are widely distributed throughout the animal kingdom. The C. elegans genome encodes a single GPHR family member, FSHR-1, which shares equal identity to the FSH, LH, and TSH receptors from mammals. RESULTS: Because loss of fshr-1 function does not produce a visible phenotype in C. elegans, we conducted a genome-wide RNAi-feeding screen to identify genes that perform functions that overlap with those of fshr-1. This approach led to the identification of the PUF family members fbf-1 and fbf-2 (the fbfs). Whereas a weak reduction in fbf activity caused little or no discernable effect in the wild-type, an equivalent loss in the fshr-1(0) mutant background resulted in a highly penetrant germline-masculinization phenotype. Furthermore, many fshr-1(0);fbf(RNAi) animals failed to maintain a germline stem cell niche. We also show that fshr-1 and the fbfs promote germline survival and prevent apoptosis with fog-1 and fog-3 and that simultaneous loss of fshr-1 and the fbfs can override the canonical requirement for fog-1 and fog-3 in the execution of the male-germline fate. Finally, we provide evidence that FSHR-1 controls germline processes nonautonomously via the soma and that FSHR-1 acts through a canonical signaling pathway involving Galpha(s) and adenyl cyclase. CONCLUSIONS: Our results indicate a conserved role for GPHR family receptors in controlling germline development and fertility. Our data suggest a model whereby FSHR-1 signaling acts in parallel to the known sex-determination pathway to control multiple aspects of germline development.

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Publishing Authors By Initials

S Cho,KW Rogers,DS Fay,

For similar cells: stem cells research abstracts see: cells: stem cells research

PUBMED ID PMID:

MEDLINE DATE:

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 203-12

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 6

MONTH: Feb

YEAR: 2007

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107782

The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: cytology

Chemical & Substance for Abstract: The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival.

AFFILIATION: University of Wyoming, College of Agriculture, Department of Molecular Biology, Department 3944, 1000 E. University Avenue, Laramie, Wyoming 82071, USA.

Country: England

AGENCY: United States NCRR

GRANT: P20 RR016474

ACRONYM: RR

MEDLINETA: Curr Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The C elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival Related Publications

• A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa.
• Application of multiresolution spatial filters to long-axis tracking.
• Are binaural cues available for sound source localization in teleost fishs?
• C-reactive protein enhances tissue factor expression by vascular smooth muscle cells: mechanisms and in vivo significance.
• Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.
• Elimination and exchange of trifluoroacetate counter-ion from cationic peptides: a critical evaluation of different approaches.
• Factor VIII A1 domain residues 97-105 represent a light chain-interactive site.
• Genetic mapping and manipulation: Chapter 1-Introduction and basics.
• Genetic mapping and manipulation: Chapter 2-Two-point mapping with genetic markers.
• Genetic mapping and manipulation: Chapter 3-Three-point mapping with genetic markers.
• Genetic mapping and manipulation: Chapter 5-SNPs: Three-point mapping.
• Genetic mapping and manipulation: Chapter 6-Mapping with deficiencies and duplications.
• Genetic mapping and manipulation: Chapter 7-Making compound mutants.
• Genetic mapping and manipulation: Chapter 9-Synthetic and enhancer mutations.
• Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds.
• Identification of Residues Contributing to A2 Domain-dependent Structural Stability in Factor VIII and Factor VIIIa.
• Mass spectrometry in nutrition: understanding dietary health effects at the molecular level.
• ORAL HEALTH CONDITIONS AMONG PERSONNEL OF THE CHINESE ARMY.
• Plant genome horizons: Michael Bennett's contribution to genome research.
• Plasminogen activator inhibitor-1 and restenosis.
• Punctuated genome size evolution in Liliaceae.
• Putting the public back into public health: one city's experience.
• Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C.
• Shoulder kinematics and kinetics during two speeds of wheelchair propulsion.
• Spectral contrasts underlying auditory stream segregation in goldfish (Carassius auratus).
• Synthetic medium for susceptibility testing.
• THE QUEQUECHAN RIVER IMPROVEMENT, FALL RIVER: A MILLION DOLLAR PROJECT IN MUNICIPAL HOUSEKEEPING.
• The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival.
• Towards a Phylogeny for Coffea (Rubiaceae): Identifying Well-supported Lineages Based on Nuclear and Plastid DNA Sequences.
• Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles.