The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Abstract Text:

Sanjeevkumar R Patel,Doyeob Kim,Inna Levitan,Gregory R Dressler,Sanjeevkumar R Patel,Doyeob Kim,Inna Levitan,Gregory R Dressler,Sanjeevkumar R Patel,Doyeob Kim,Inna Levitan,Gregory R Dressler,

The MLL family of histone methyltransferases maintains active chromatin domains by methylating histone H3 on lysine 4 (H3K4). How MLL complexes recognize specific chromatin domains in a temporal and tissue-specific manner remains unclear. We show that the DNA-binding protein PAX2 promotes assembly of an H3K4 methyltransferase complex through the ubiquitously expressed nuclear factor PTIP (pax transcription activation domain interacting protein). PTIP copurifies with ALR, MLL3, and other components of a histone methyltransferase complex. PTIP promotes assembly of the ALR complex and H3K4 methylation at a PAX2-binding DNA element. Without PTIP, Pax2 binds to this element but does not assemble the ALR complex. Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation.

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Publishing Authors By Initials

SR Patel,D Kim,I Levitan,GR Dressler,SR Patel,D Kim,I Levitan,GR Dressler,SR Patel,D Kim,I Levitan,GR Dressler,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental cell

VOLUME: 13

Page Numbers: 580-92

Journal Abbreviation: Dev. Cell

ISSN: 1534-5807

DAY: 10

MONTH: Oct

YEAR: 2007

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101120028

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

AFFILIATION: Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK073722

ACRONYM: DK

MEDLINETA: Dev Cell

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex Related Publications

• A comparative study of five fatal cases of Taxus poisoning.
• A new strategy on pitch estimation in polyphonic musical audio.
• Another niche for Notch.
• Botulinum toxin drugs: future developments.
• Botulinum toxin treatment of axial and cervical dystonia.
• Centrifugation of rickettsiae and viruses onto cells and its effect on infection.
• Cerebral air embolism associated with spontaneous pneumothorax.
• DNA flow cytometry measurements and their clinical relevance in node-negative breast cancer patients.
• Digit ratio (2D:4D) in Lithuania once and now: testing for sex differences, relations with eye and hair color, and a possible secular change.
• Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342.
• Osteopathic education looks ahead.
• PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.
• Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia.
• Percussion of the sternum. I. Aid to differentiation of pericardial effusion and cardiac dilatation.
• Phenotypic ranges and relationships among carcass and meat palatability traits for fourteen cattle breeds, and heritabilities and expected progeny differences for Warner-Bratzler shear force in three beef cattle breeds.
• The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
• The cellular basis of kidney development.
• Topical application of mafenide acetate. Its association with erythema multiforme and cutaneous reactions.
• [An improved model of a catheterised human bladder for screening bactericidal agents.]
• [Anal pain.]
• [Categories of kinetic visual acuity in a study group; the characteristics of the curves]
• [Current outlook on botulinum toxin medications]
• [Essay of physio-pathology of graded tubage. I. Participation of the duodenum in certain anomalies and, especially, of Oddi's closure time and in time of bile.]
• [Hemorrhagic macular choroidopathy in young adults; the problems of diagnosis and treatment]
• [Kinetic visual acuity (KVA) as a function of the form and color of the visual tests employed]
• [Kinetic visual acuity (KVA)]
• [Kinetic visual acuity as a function of age, fatigue, training and natural selection of female textile workers at various work stations]
• [Kinetic visual acuity as a means of functional examination in ophthalmology]
• [Spontaneous ciliochoroidal detachment (a case report)]
• [Systematic investigation of digestive tract tumors by a scaled clinical pre-investigation technic.]