The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats.

The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Research Abstract Details 

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The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Abstract Text:

M D Day,A G Roach,

1. DL-Propranolol, L-propranolol, DL-alprenolol, pindolol (LB46), practolol, ICI 66082, sotalol and oxprenolol all produced prolonged falls in blood pressure and heart rate after intracerebroventricular administration in conscious normotensive cats. 2. Transient initial pressor responses and tachycardias were observed after intracerebroventricular infusions of all the beta-adrenoceptor antagonists used, except ICI 66082. 3. D-Propranolol, D-alphrenolol, procaine and lignocaine all produced initial increases in blood pressure and heart rate but did not subsequently cause any reduction in either blood pressure or heart rate. 4. The time of maximum hypotension and bradycardia after intracerebroventricular infusion of beta-adrenoceptor antagonists coincided with the maximum inhibition of the centrally mediated tachycardia observed after intracerebroventricular isoprenaline.

The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Publishing Authors By Initials

MD Day,AG Roach,

For similar organic chemicals: alcohols: amino alcohols: ethanolamines: sotalol research abstracts see: organic chemicals: alcohols: amino alcohols: ethanolamines: sotalol research

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The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 2

Page Numbers: 269s-272s

Journal Abbreviation:

ISSN: 0144-4107

DAY: 12

MONTH: Jun

YEAR: 1975

The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Information

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LANGUAGE: eng

NlmUniqueID: 7907311

The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Keywords Mesh Terms:

KEYWORDS: Sotalol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats. Information

Substance Name: Practolol

Registry Number: 6673-35-4

Grant and Affiliation Information for The brain as a possible site for the cardiovascular effects of beta-adrenoceptor blocking agents in cats.

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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