The Binding of Antibiotics to ERp57/GRP58.

The Binding of Antibiotics to ERp57/GRP58. Research Abstract Details 

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The Binding of Antibiotics to ERp57/GRP58. Abstract Text:

The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.

The Binding of Antibiotics to ERp57/GRP58. Publishing Authors By Initials

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The Binding of Antibiotics to ERp57/GRP58. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of antibiotics

VOLUME: 61

Page Numbers: 400-2

Journal Abbreviation: J. Antibiot.

ISSN: 0021-8820

DAY: 31

MONTH: Jun

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 151115

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Grant and Affiliation Information for The Binding of Antibiotics to ERp57/GRP58.

AFFILIATION: Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza-Università di Roma.

Country: Japan

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MEDLINETA: J Antibiot (Tokyo)

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