The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Research Abstract Details 

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The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Abstract Text:

Michael D Kim,Lily Yeh Jan,Yuh Nung Jan,

Dendrites exhibit a wide range of morphological diversity, and their arborization patterns are critical determinants of proper neural connectivity. How different neurons acquire their distinct dendritic branching patterns during development is not well understood. Here we report that Spineless (Ss), the Drosophila homolog of the mammalian aryl hydrocarbon (dioxin) receptor (Ahr), regulates dendrite diversity in the dendritic arborization (da) sensory neurons. In loss-of-function ss mutants, class I and II da neurons, which are normally characterized by their simple dendrite morphologies, elaborate more complex arbors, whereas the normally complex class III and IV da neurons develop simpler dendritic arbors. Consequently, different classes of da neurons elaborate dendrites with similar morphologies. In its control of dendritic diversity among da neurons, ss likely acts independently of its known cofactor tango and through a regulatory program distinct from those involving cut and abrupt. These findings suggest that one evolutionarily conserved role for Ahr in neuronal development concerns the diversification of dendrite morphology.

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Publishing Authors By Initials

MD Kim,LY Jan,YN Jan,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research

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The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes & development

VOLUME: 20

Page Numbers: 2806-19

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 2

MONTH: 10

YEAR: 2006

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Keywords Mesh Terms:

KEYWORDS: Receptors, Aryl Hydrocarbon

MESH TERMS: metabolism

Chemical & Substance for Abstract: The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Information

Substance Name: spineless protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.

AFFILIATION: Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS40929

ACRONYM: NS

MEDLINETA: Genes Dev

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