The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.

The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Research Abstract Details 

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The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Abstract Text:

S M Rawls,R Tallarida,W Robinson,M Amin,

BACKGROUND AND PURPOSE: Beta-lactam antibiotics are the first practical pharmaceuticals capable of increasing the expression and activity of the glutamate transporter, GLT-1, in the CNS. However, the functional impact of beta-lactam antibiotics on specific drugs which produce their pharmacological effects by increasing glutamatergic transmission is unknown. One such drug is morphine, which causes hyperthermia in rats, mediated by an increase in glutamatergic transmission. Since drugs (e.g. antibiotics) that enhance glutamate uptake also decrease glutamatergic transmission, we tested the hypothesis that ceftriaxone, a beta-lactam antibiotic, would block the glutamate-dependent portion of morphine-evoked hyperthermia. EXPERIMENTAL APPROACH: A body temperature assay was used to determine if ceftriaxone decreased morphine-induced hyperthermia in rats by increasing glutamate uptake. KEY RESULTS: Body temperatures of rats treated with ceftriaxone (200 mg kg(-1), i.p. x 7 days) did not differ from rats receiving saline. Morphine (1, 4, 8 and 15 mg kg(-1), s.c.) caused significant hyperthermia. Pre-treatment with ceftriaxone, as described above, decreased the hyperthermic response to these doses of morphine. The effects of ceftriaxone were prevented by TBOA (0.2 micromol, i.c.v.), an inhibitor of glutamate transport. CONCLUSIONS AND IMPLICATIONS: Ceftriaxone attenuated the hyperthermia caused by morphine, an effect prevented by inhibiting glutamate transport. Thus this effect of ceftriaxone was most likely mediated by increased glutamate uptake. These data revealed a functional interaction between ceftriaxone and morphine and indicated that a beta-lactam antibiotic decreased the efficacy of morphine in conscious rats.

The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Publishing Authors By Initials

SM Rawls,R Tallarida,W Robinson,M Amin,

For similar organic chemicals: amides: lactams: beta-lactams research abstracts see: organic chemicals: amides: lactams: beta-lactams research

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The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: British journal of pharmacology

VOLUME: 151

Page Numbers: 1095-102

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 25

MONTH: 06

YEAR: 2007

The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7502536

The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Keywords Mesh Terms:

KEYWORDS: beta-Lactams

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats. Information

Substance Name: Ceftriaxone

Registry Number: 73384-59-5

Grant and Affiliation Information for The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.

AFFILIATION: Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA 19140, USA. scott.rawls@temple.edu

Country: England

AGENCY: United States NIDA

GRANT: DA 09793-03

ACRONYM: DA

MEDLINETA: Br J Pharmacol

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