The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Research Abstract Details 

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The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Abstract Text:

Romesh A Draviam,Stuart H Shand,Simon C Watkins,

Mutations of any of the sarcoglycan complex subunits (alpha, beta, delta, and gamma) cause limb-girdle muscular dystrophy. Furthermore, individual mutations lead to a reduction or loss of all other members of the complex. In some cases of limb-girdle muscular dystrophies, however, residual sarcoglycan expression has been documented. Therefore, in this study we tested the hypothesis that formation of specific sarcoglycan subcomplexes is crucial for plasma membrane deposition. Using co-immunoprecipitation assays, we demonstrated that beta- and delta-sarcoglycan interact with alpha-sarcoglycan and these two subunits must be co-expressed for export from the endoplasmic reticulum. Advanced light-microscopic imaging techniques demonstrated that co-expression of beta-sarcoglycan and delta-sarcoglycan is also responsible for delivery to and retention of sarcoglycan subcomplexes at the cell surface. These data suggest that formation of the beta-delta-core may promote the export and deposition of sarcoglycan subcomplexes at the plasma membrane, and therefore identifies a mechanism for sarcoglycan transport.

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Publishing Authors By Initials

RA Draviam,SH Shand,SC Watkins,

For similar cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: golgi apparatus: trans-golgi network research abstracts see: cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: golgi apparatus: trans-golgi network research

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The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Muscle & nerve

VOLUME: 34

Page Numbers: 691-701

Journal Abbreviation: Muscle Nerve

ISSN: 0148-639X

DAY: 3

MONTH: Dec

YEAR: 2006

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803146

The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Keywords Mesh Terms:

KEYWORDS: trans-Golgi Network

MESH TERMS: metabolism

Chemical & Substance for Abstract: The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Information

Substance Name: Green Fluorescent Proteins

Registry Number: 147336-22-9

Grant and Affiliation Information for The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane.

AFFILIATION: Department of Cell Biology and Molecular Physiology, University of Pittsburgh School of Medicine, S224 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: U54-AR050733

ACRONYM: AR

MEDLINETA: Muscle Nerve

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