The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria.

The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Research Abstract Details 

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The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Abstract Text:

Joscelyn M Tatro,Naoya Taki,Andrew S Islam,Victor M Goldberg,Clare M Rimnac,Claire M Doerschuk,Matthew C Stewart,Edward M Greenfield,

Bacterial endotoxin may contribute to aseptic loosening of orthopedic implants even in the absence of clinical or microbiological evidence of infection. One potential source of endotoxin during aseptic loosening is systemically circulating endotoxin, derived from intestinal flora, minor infections, or dental procedures, that may bind to wear particles. The current study demonstrates that systemically derived endotoxin accumulates when 'endotoxin-free' titanium and polyethylene particles are implanted on murine calvaria. Time-course experiments and experiments using germ-free mice rule out the possibility that the observed endotoxin accumulation may be due to bacterial contamination. In contrast, endotoxin is cleared from titanium particles that originally carry high amounts of adherent endotoxin. The mechanism of endotoxin clearance is not dependent on induction of a respiratory burst. Taken together, these results indicate that a balance between endotoxin accumulation and endotoxin clearance controls the steady-state level of endotoxin surrounding orthopedic wear particles implanted on murine calvaria. This balance may regulate the rate of osteolysis in the murine calvaria model as well as in patients with aseptic loosening.

The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Publishing Authors By Initials

JM Tatro,N Taki,AS Islam,VM Goldberg,CM Rimnac,CM Doerschuk,MC Stewart,EM Greenfield,

For similar inorganic chemicals: elements: metals, light: titanium research abstracts see: inorganic chemicals: elements: metals, light: titanium research

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The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of orthopaedic research : official publica

VOLUME: 25

Page Numbers: 361-9

Journal Abbreviation: J. Orthop. Res.

ISSN: 0736-0266

DAY: 3

MONTH: Mar

YEAR: 2007

The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8404726

The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Keywords Mesh Terms:

KEYWORDS: Titanium

MESH TERMS: adverse effects

Chemical & Substance for Abstract: The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria. Information

Substance Name: Polyethylene

Registry Number: 9002-88-4

Grant and Affiliation Information for The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria.

AFFILIATION: Department of Orthopadics, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106-5000, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR43769

ACRONYM: AR

MEDLINETA: J Orthop Res

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