The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease.

The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Research Abstract Details 

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The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Abstract Text:

Hendrik Schultz,Jerrold P Weiss,

Gram-negative bacteria (GNB) and their endotoxin present a constant environmental challenge. Endotoxins can potently signal mobilization of host defenses against invading GNB but also potentially induce severe pathophysiology, necessitating controlled initiation and resolution of endotoxin-induced inflammation to maintain host integrity. The bactericidal/permeability-increasing protein (BPI) is a pluripotent protein expressed, in humans, mainly neutrophils. BPI exhibits strong antimicrobial activity against GNB and potent endotoxin-neutralizing activity. BPI mobilized with neutrophils in response to invading GNB can promote intracellular and extracellular bacterial killing, endotoxin neutralization and clearance, and delivery of GNB outer membrane antigens to dendritic cells. Tissue expression by dermal fibroblasts and epithelia could further amplify local levels of BPI and local interaction with GNB and endotoxin, helping to constrain local tissue infection and inflammation and prevent systemic infection and systemic inflammation. This review article focuses on the structural and functional properties of BPI with respect to its contribution to host defense during GNB infections and endotoxin-induced inflammation and the genesis of autoantibodies against BPI that can blunt BPI activity and potentially contribute to chronic inflammatory disease.

The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Publishing Authors By Initials

H Schultz,JP Weiss,

For similar proteins: membrane proteins research abstracts see: proteins: membrane proteins research

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The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinica chimica acta; international journal of cli

VOLUME: 384

Page Numbers: 12-23

Journal Abbreviation: Clin. Chim. Acta

ISSN: 0009-8981

DAY: 13

MONTH: 07

YEAR: 2007

The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Information

Number of References: 134

LANGUAGE: eng

NlmUniqueID: 1302422

The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Keywords Mesh Terms:

KEYWORDS: Membrane Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Information

Substance Name: bactericidal permeability increasing pro

Registry Number: 0

Grant and Affiliation Information for The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease.

AFFILIATION: Division of Infectious Diseases, University of Iowa, and Iowa City VAMC, USA, Iowa City, Iowa 52242, USA. Hendrik-Schultz@uiowa.edu

Country: Netherlands

AGENCY: United States PHS

GRANT: P0144642

ACRONYM: AI

MEDLINETA: Clin Chim Acta

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