The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Research Abstract Details 

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The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Abstract Text:

Janet Hall,Mia Hashibe,Paolo Boffetta,Valerie Gaborieau,Norman Moullan,Amelie Chabrier,David Zaridze,Oxana Shangina,Neonila Szeszenia-Dabrowska,Dana Mates,Vladimir Janout, ,Ivana Holcatova,Rayjean J Hung,James McKay,Federico Canzian,Paul Brennan,

Cancers of the upper aerodigestive tract (UADT), comprising the oral cavity, pharynx, larynx and oesophagus, account for 5.2% of all cancers cases worldwide. The major risk factors, tobacco and alcohol can directly or indirectly generate DNA damage, which if unrepaired can give rise to mutations, unregulated cell growth and apoptosis induction. To clarify the role of DNA repair and cell cycle control proteins in UADT cancer susceptibility, we studied the risk in relation to 28 SNPs in 18 DNA repair enzymes and 9 SNPs in 7 cell cycle control genes. A case-control study was conducted from 2000 to 2002 in six centers from Romania, Poland, Russia, Slovakia and the Czech Republic. Patients diagnosed with squamous cell carcinoma of the UADT (n=811) and controls with a recent diagnosis of diseases unrelated to tobacco and alcohol (n=1083) were recruited. For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009). Several other sequence variants showed associations with specific cancers without an overall association with UADT cancer. While some of these associations are consistent with previous studies, we cannot rule out the possibility of false-positive associations. The positive findings should be explored in another large-scale study on UADT cancers.

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Publishing Authors By Initials

J Hall,M Hashibe,P Boffetta,V Gaborieau,N Moullan,A Chabrier,D Zaridze,O Shangina,N Szeszenia-Dabrowska,D Mates,V Janout,E ,I Holcatova,RJ Hung,J McKay,F Canzian,P Brennan,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 665-71

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 13

MONTH: 10

YEAR: 2006

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Information

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LANGUAGE: eng

NlmUniqueID: 8008055

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: adverse effects

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Grant and Affiliation Information for The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.

AFFILIATION: International Agency for Research on Cancer, Lyon, France.

Country: England

AGENCY: United States NCI

GRANT: R01 CA 092039-01A2

ACRONYM: CA

MEDLINETA: Carcinogenesis

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