The association of OSA with insulin resistance, inflammation and metabolic syndrome.

The association of OSA with insulin resistance, inflammation and metabolic syndrome. Research Abstract Details 

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The association of OSA with insulin resistance, inflammation and metabolic syndrome. Abstract Text:

Nir Peled,Micha Kassirer,David Shitrit,Yivgeny Kogan,Dekel Shlomi,Abraham Shlomo Berliner,Mordechai Reuven Kramer,

Obstructive sleep apnea (OSA) shares many cardiovascular risk factors with metabolic syndrome, including obesity, hypertension, insulin resistance, and pro-inflammatory state. This study aimed to examine the possible association of OSA severity with insulin resistance, inflammation and the metabolic syndrome. Ninety eight patients suspected for OSA (54.9+/-13.1 years) were studied. Overnight polysomnography and blood sampling was taken for glucose, insulin, high-density lipoprotein(HDL)-cholesterol, triglycerides, high-sensitivity C-reactive protein (Hs-CRP), and serum amyloid A (S-AA). Insulin resistance was estimated by the homeostatic model assessment (HOMA). Each patient was assigned a metabolic score according to the number of discrete components of metabolic syndrome identified, and categorized by OSA severity. Nine patients had primary snoring, nine had mild, 27 moderate and 53 severe OSA. Metabolic score increased from 1.56+/-1.01 to 2.92+/-1.20 with OSA severity (p=0.004), and was correlated independently with apnea hypopnea index (AHI; r=0.432, p=0.001) and with body mass index (BMI; r=0.518 p=0.001). Hs-CRP increased from 3.44+/-4.25 to 5.87+/-4.76mg/dL with OSA severity (p=0.066) and correlated with AHI (r=0.348; p=0.002). Insulin resistance, correlated significantly with AHI (r=0.390 p=0.021). Inflammation, insulin resistance and metabolic syndrome increase with OSA severity. The number of cardinal features of metabolic syndrome increases with an increase in OSA severity, regardless of the BMI.

The association of OSA with insulin resistance, inflammation and metabolic syndrome. Publishing Authors By Initials

N Peled,M Kassirer,D Shitrit,Y Kogan,D Shlomi,AS Berliner,MR Kramer,

For similar respiratory tract diseases: respiration disorders: apnea: sleep apnea syndromes: sleep apnea, obstructive research abstracts see: respiratory tract diseases: respiration disorders: apnea: sleep apnea syndromes: sleep apnea, obstructive research

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The association of OSA with insulin resistance, inflammation and metabolic syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Respiratory medicine

VOLUME: 101

Page Numbers: 1696-701

Journal Abbreviation:

ISSN: 0954-6111

DAY: 26

MONTH: 04

YEAR: 2007

The association of OSA with insulin resistance, inflammation and metabolic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8908438

The association of OSA with insulin resistance, inflammation and metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Sleep Apnea, Obstructive

MESH TERMS: complications

Chemical & Substance for Abstract: The association of OSA with insulin resistance, inflammation and metabolic syndrome. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for The association of OSA with insulin resistance, inflammation and metabolic syndrome.

AFFILIATION: Pulmonary Institute, Rabin Medical Center, Beilinson Campus, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Country: England

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MEDLINETA: Respir Med

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