The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma.

The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Research Abstract Details 

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The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Abstract Text:

S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,

BACKGROUND: DNA repair enzymes repair some of the DNA damage associated with risk factors for renal cell carcinoma (RCC), including smoking. DNA repair gene polymorphisms modulate the repair capacity and might influence individual risk and progression of RCC. We examined associations between functional polymorphisms and risk, clinicopathologic characteristics and survival of RCC. PATIENTS AND METHODS: The study groups comprised 215 RCC patients and 215 age- and gender-matched healthy controls. Polymorphisms in xeroderma pigmentosum complementation groups C, D and G and X-ray repair cross-complementing groups 1 and 3 genes were genotyped. RESULTS: No significant differences in DNA repair genotype were observed between RCC cases and controls. In all patients, however, greater numbers (>/=3) of total variant alleles in all DNA repair genes studied were associated with less frequent venous extension (P = 0.0079). In smokers, some genotypes were associated with characteristics of RCC (Ps

The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Publishing Authors By Initials

S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,S Sakano,Y Hinoda,N Okayama,Y Kawai,Y Korenaga,S Eguchi,K Nagao,C Ohmi,K Naito,

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The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of oncology : official journal of the Europ

VOLUME: 18

Page Numbers: 1817-27

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ISSN: 0923-7534

DAY: 21

MONTH: 08

YEAR: 2007

The association of DNA repair gene polymorphisms with the development and progression of renal cell carcinoma. Information

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LANGUAGE: eng

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AFFILIATION: Department of Urology.

Country: England

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MEDLINETA: Ann Oncol

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